نتایج جستجو برای: excitotoxicity

تعداد نتایج: 2624  

Journal: :Trends in Neurosciences 2021

Excitotoxicity is likely to occur in pathological scenarios which mitochondrial function already compromised, shaping neuronal responses glutamate. In fact, mitochondria sustain cell bioenergetics, tune intracellular Ca2+ dynamics, and regulate glutamate availability by using it as metabolic substrate. Here, we suggest the need explore toxicity context of specific disease models may ...

Journal: :Scientific Reports 2021

Abstract Excess glutamate in the central nervous system may be a major cause of neurodegenerative diseases with gradual loss and dysfunction neurons. Primary or secondary metabolites from medicinal plants algae show potential for treatment glutamate-induced excitotoxicity. Three plant extracts were evaluated impact on excitotoxicity-induced primary cultures retinal ganglion cells (RGC). These t...

Journal: :Medical research archives 2022

Alzheimer’s disease is the most common form of dementia affecting older adults. also shares a significant association with Major Depressive Disorder. Glutamatergic excitotoxicity via NMDA receptors believed to be key mechanism underlying neurodegeneration in Disease. Blockade by antagonists like Memantine appears inhibit glutamatergic excitotoxicity. increases dopaminergic activation through ag...

Bernhard Wünsch, Dirk Schepmann, Heinz Wiendl, Sarah Glumm, Stefan Bittner, Sven G Meuth, Tobias Ruck,

Glutamate-mediated excitotoxicity and neurodegeneration have been shown as pathophysiological hallmarks of multiple sclerosis (MS) and other autoimmune inflammatory CNS disorders. N‑Methyl‑D‑Aspartate (NMDA) receptors play a pivotal role in the mediation of neuronal glutamate excitotoxicity leading to cellular damage and apoptotic cell death. Current treatment approaches targeting glutamate exc...

Journal: :The Journal of biological chemistry 2006
Wenbin Deng Rachael L Neve Paul A Rosenberg Joseph J Volpe Frances E Jensen

Developing oligodendrocytes (OLs) are highly vulnerable to glutamate excitotoxicity. Although OL excitotoxicity is mainly mediated by alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors (AMPARs) and is Ca2+-dependent, the molecular basis for AMPAR-mediated Ca2+ influx in OLs remains largely unclear. Ca2+ permeability of AMPARs is inversely correlated with the abundance of the...

Journal: :مجله علوم اعصاب شفای خاتم 0
sarah glumm department of translational neurology, university of münster, münster, germany tobias ruck department of translational neurology, university of münster, münster, germany dirk schepmann department of pharmaceutical and medical chemistry, university of münster, münster, germany heinz wiendl department of translational neurology, university of münster, münster, germany bernhard wünsch department of pharmaceutical and medical chemistry, university of münster, münster, germany stefan bittner department of neurology, university of mainz, mainz, germany

glutamate-mediated excitotoxicity and neurodegeneration have been shown as pathophysiological hallmarks of multiple sclerosis (ms) and other autoimmune inflammatory cns disorders. n‑methyl‑d‑aspartate (nmda) receptors play a pivotal role in the mediation of neuronal glutamate excitotoxicity leading to cellular damage and apoptotic cell death. current treatment approaches targeting glutamate exc...

2015
Nur Shafika Mohd Sairazi K. N. S. Sirajudeen Mohd Asnizam Asari Mustapha Muzaimi Swamy Mummedy Siti Amrah Sulaiman

Excitotoxicity is well recognized as a major pathological process of neuronal death in neurodegenerative diseases involving the central nervous system (CNS). In the animal models of neurodegeneration, excitotoxicity is commonly induced experimentally by chemical convulsants, particularly kainic acid (KA). KA-induced excitotoxicity in rodent models has been shown to result in seizures, behaviora...

2017
Yu Wu Changwan Chen Qian Yang Mingfei Jiao Shuang Qiu

Abstract N-methyl-D-aspartate (NMDA) receptor overactivation is involved in neuronal damage after stroke. However, the mechanism underlying NMDA receptor-mediated excitotoxicity remains unclear. In this study, we confirmed that excessive activation of NMDARs led to cell apoptosis in PC12 cells and in primary cultured cortical neurons, which was mediated predominantly by the GluN2B-containing, b...

2011
Xiang-Yu Zheng Hong-Liang Zhang Qi Luo Jie Zhu

Excitotoxicity is considered to be an important mechanism involved in various neurodegenerative diseases in the central nervous system (CNS) such as Alzheimer's disease (AD). However, the mechanism by which excitotoxicity is implicated in neurodegenerative disorders remains unclear. Kainic acid (KA) is an epileptogenic and neuroexcitotoxic agent by acting on specific kainate receptors (KARs) in...

Journal: :physiology and pharmacology 0
ali shahraki zahedan, department of biology, faculty of science, university of sistan and baluchestan

metabotropic glutamate receptors (mglurs) consist of a large family of g-protein coupled receptors that are critical for regulating normal neuronal function in the central nervous system. the wide distribution and diverse physiological roles of various mglur subtypes make them highly attractive targets for the treatment of a number of neurological and psychiatric disorders. the discovery of sub...

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