This study was designed to assess the effectiveness of a modified silk ligature twisted with wire for inducing advanced periodontitis. Periodontitis was induced in five premolars and one molar of 20 healthy dogs over a 60-day period. The dogs were divided into four groups according to the ligature-inducing materials used: soft moistened food only, wire ligature (WL), silk ligature (SL) and twis...

Periodontitis is a chronic infectious disease for which the fundamental treatment is to reduce the load of subgingival pathogenic bacteria by debridement. However, previous investigators attempted to implement a nuclear factor kappa B (NF-κB) decoy oligodeoxynucleotide (ODN) as a suppressor of periodontitis progression. Although we recently reported the effectiveness of the ultrasound-microbubb...

background: c-reactive protein (crp) is an acute phase reactant and has been proved to be a significant predictor of future cardiovascular events. recent studies have demonstrated a correlation between periodontitis and elevated crp levels. however, comparison between the levels of crp in two main forms of periodontitis is ambiguous. this study aims at determining and comparing the relative lev...

Introduction and objectives: positive correlation have been seen between high salivary calcium content and periodontal disease. This study was designed to compare inorganic salivary calcium, phosphate, flow rate and ph, of paraffin wax stimulated saliva of patients with gingivitis; mild periodontitis; moderate periodontitis; severe periodontitis. Methods: the present study consisted of 125 pati...

background and aims. along with conventional periodontal therapy, subginigval application of platelet-rich plasma (prp) may provide more effective improvements in clinical parameters due to the presence of multiple growth factors. the aim of this double-blind, split-mouth, randomized study was to evaluate the adjunctive use of prp with scaling and root planing (srp) in the treatment of chronic ...

The reconstruction of large osseous defects due to periodontitis is a challenge in regenerative therapy. Sclerostin, secreted by osteocytes, is a key physiological inhibitor of osteogenesis. Pharmacologic inhibition of sclerostin using sclerostin-neutralizing monoclonal antibody (Scl-Ab) thus increases bone formation, bone mass and bone strength in models of osteopenia and fracture repair. This...

Periodontal diseases are multifactorial, caused by polymicrobial subgingival pathogens, including Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia. Chronic periodontal infection results in inflammation, destruction of connective tissues, periodontal ligament, and alveolar bone resorption, and ultimately tooth loss. Enoxacin and a bisphosphonate derivative of enoxacin (bis...

BACKGROUND The association between periodontitis and atherosclerotic cardiovascular diseases (ACVD) has been established in some modestly sized studies (<10 000). Rarely, however, periodontitis has been studied directly; often tooth loss or self-reported periodontitis has been used as a proxy measure for periodontitis. Our aim is to investigate the adjusted association between periodontitis and...

Periodontitis is defined as inflammation affecting the supporting tissue of teeth. Periodontal pathogens initiate the disease and induce inflammatory host response. Hypoxia may accelerate the process by producing pro-inflammatory factors. The aim of this study is to investigate the effect of Porphyromonas gingivalis (P. gingivalis) lipopolysaccharides (LPS) and Escherichia coli (E. coli) LPS in...