Hypoxia, a common condition of the tumor microenvironment, is associated with poor patient prognosis, tumor cell migration, invasion and metastasis. Recent evidence suggests that hypoxia alters endosome dynamics in tumor cells, leading to augmented cell proliferation and migration and this is particularly relevant, because endosomal components have been shown to be deregulated in cancer. The ea...

Lysophosphatidylcholine (LysoPC) is an important intermediate in degradation and biosynthesis of phosphatidylcholine (PC). Reduced plasma LysoPC levels observed in patients with advanced cancer indicate a deregulation of LysoPC metabolism in metastasis. Recent data showed strong antimetastatic effects of liposomes consisting of saturated PC in a murine pancreatic metastasis model. LysoPC, gener...

We describe Green’s relations on the partition monoid, two of its submonoids, and the related Jones and Brauer monoids. Key Words: partition monoid, Jones monoid, ideal structure 2000 Mathematics Subject Classi…cation: 20M20 1 The partition monoid and some submonoids The elements of the partition monoid Pn [5, 8, 9] are equivalence classes of graphs on a vertex set n [ n0 = f1; 2; :::ng [ f10; ...

UNLABELLED It is highly desired to develop new imaging probes for early detection of melanoma as early diagnosis and prompt surgical removal are a patient's best hope for a cure. The purpose of this study was to determine whether (99m)Tc- and (111)In-labeled alpha-melanocyte-stimulating hormone (alpha-MSH) peptides could be used as imaging probes for primary and metastatic melanoma using dual-m...

The paper enquires into the e¤ects of China’s entry into the WTO on its economic growth. We ...nd that even in the short run (2001-2005), economic performance can be improved due to obtaining higher survival probability of economic growth rate and better protection of consumer welfare. JEL classi...cation: F10, O10

Using a three-sector general equilibrium model with non-traded goods, we investigate the impact of foreign direct investment on the real wages of skilled and unskilled workers. We show that foreign direct investment increases the real wages of skilled and unskilled workers, but widens the gap between the two under plausible conditions. JEL: F10, F11, F21

An organophosphorus-resistant strain of Culex quinquefasciatus was pressured with pyriproxyfen for 17 generations. Egg viability began declining in the F7 generation and became lower as the selection process continued; by the F17 generation egg viability was too low to proceed further. Susceptibility tests on larvae of the F5, F10, F15, and F17 generations showed no indication of increased tole...

Abstract Patients with locally advanced and metastatic urothelial carcinoma have a low survival rate (median 15.7 months, 13.1–17.8), 23% response to monotherapy treatment anti-PD-L1 immunotherapy. We recently reported the potent effects of i.v. infusions immune modifying poly(lactic-co-glycolic acid) (PLGA) nanoparticles (IMPs; named ONP-302) both decrease B16.F10, MC-38, LLC, 4T1 tumor growth...

Cancer develops and progresses as genetic alterations occur subsequently. Onset process of cancer has become well understood in some types of cancer, such as colorectal cancers. In this process, responsible alterations were identified in numbers of oncogenes such as k-ras, and tumor suppressor genes such as p53, as Vogelstein proposed earlier in the multistage carcinogenesis theory. In contrast...

Immunotherapy approaches currently make their way into the clinics to improve the outcome of standard radiochemotherapy (RCT). The programed cell death receptor ligand 1 (PD-L1) is one possible target that, upon blockade, allows T cell-dependent antitumor immune responses to be executed. To date, it is unclear which RCT protocol and which fractionation scheme leads to increased PD-L1 expression...