background: it is presumed that gastric cancer has several etiologies. first-degree relatives of patients with gastric cancer are suggested to be at higher risk compared to others. this is the first study aimed at estimating this risk, using meta-analysis of case-control studies. materials and methods: all records prior to february 2008 in pubmed and embase were searched for case-control studie...

BACKGROUND Familial clustering of incident prostate cancer and some cancers at other discordant sites has been reported. Less is known about familial clustering of fatal prostate cancer with any fatal discordant cancers. Estimates on familial aggregation based on mortality are free from bias of overdiagnosis. PATIENTS AND METHODS We used the nationwide Swedish Family-Cancer Database to calcul...

BACKGROUND Prostate cancer is a common and often deadly cancer. Decades of study have yet to identify genes that explain much familial prostate cancer. Traditional linkage analysis of pedigrees has yielded results that are rarely validated. We hypothesize that there are rare segregating variants responsible for high-risk prostate cancer pedigrees, but recognize that within-pedigree heterogeneit...