familial defective apolipoprotein (apo) b 100 (fdb) causes early-onset coronary heart diseases (chd). it is produced by r3500q mutation of the apob gene resulting in decreased binding of ldl to ldl receptor. we screened the apo b gene for r3500q mutation in 130 hypercholesterolemic patients, among whom 30 patients met criteria of familial hypercholesterolemia (fh). the prevalence of r3500q alle...

We report on timing and spectral observations of the microquasar XTE J1550 − 564 during its 2000 outburst made by the Rossi X-ray Timing Experiment (RXTE). We study the spectral properties of the source during both the rise to the outburst and its decline. We observe transitions from a low hard state to an intermediate state, and vice versa, before the source returns to quiescence. We show that...

Background Causative genetic variants have to date been identified for only a small proportion of familial colorectal cancer (CRC). While conditions such as Familial Adenomatous Polyposis (FAP) and Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer, HNPCC) are caused by well defined genetic defects, the search for variants underlying the remainder of familial CRC is plagued by genetic he...