Objective: We aimed to evaluate the number and function of regulatory T (Treg) cells in peripheral blood prostate tissues patients with histopathologically diagnosed benign hyperplasia (BPH) asymptomatic chronic prostatitis.
 Material Methods: Blood histopathological data 19 (BPH=10, ACP=9) that underwent transurethral resection were evaluated. Treg cell count prostatic tissue flowcytometr...

Introduction: The p19 line of embryonal carcinoma cells develops into neurons, astroglia and fibroblasts after aggregation and exposure to retinoic acid (RA). Dehydroepiandroesteron (DHEA) is a neurosteroid, can increase proliferation of human neural stem cell (NSC) and positively regulated the number of neurons produced. This study was initiated to assess the effect of DHEA on neural progenito...

BACKGROUND Dendritic cells (DC) linking innate and adaptive immune responses are present in human lungs, but the characterization of different subsets and their role in COPD pathogenesis remain to be elucidated. The aim of this study is to characterize and quantify pulmonary myeloid DC subsets in small airways of current and ex-smokers with or without COPD. METHODS Myeloid DC were characteriz...

Analyzing the cytotoxic functions of effector cells, such as NK cells against target cancer cells, is thought to be necessary for predicting the clinical efficacy of antibody-dependent cellular cytotoxicity (ADCC) -dependent antibody therapy. The (51)Cr release assay has long been the most widely used method for quantification of ADCC activity. However, the reproducibilities of these release as...

BACKGROUND & OBJECTIVES Chapekar established a model of ovarian tumourigenesis in mice by splenic transplantation of ovaries, resulting in sustained luteinizing hormone (LH) levels because of absence of feedback inhibition. There is increasing evidence of the differential response to LH or hCG under various experimental conditions. The effect of sustained hormonal stimulation in long term cultu...

OBJECTIVE IL-22 is elevated in patients with inflammatory arthritis and correlates with disease activity. IL-22 deficient mice have reduced incidence of arthritis. Recombinant IL-22 restrains progression of arthritis via increase in IL-10 responses when administered prior to onset of arthritis. These findings imply a possible dual role of IL-22 in inflammatory arthritis depending on the phase o...

Black seed (Nigella sativa) is considered as a biological response modifier. Thymoquinone (TQ) is the bioactive and the most abundant constituent of the volatile oil of this seed which has been shown to possess anti-inflammatory, antioxidant and anti-neoplastic effects. In this study, the effect of TQ on HepG2 cell line was investigated in an attempt to identify its potential mechanism of actio...

The predictive value of measurable residual disease (MRD) for survival in acute myeloid leukemia (AML) has been firmly established younger patients treated with intensive chemotherapy. MRD after treatment decitabine older is unknown. This retrospective analysis included ≥60 years age AML who received an allogeneic hematopoietic cell transplantation (alloHCT) or Of the 133 consecutively transpla...