Dr K COWCHER, Mr E McELLIGOTT, and Dr G W HANKS (Royal Marsden Hospital, Sutton, Surrey SM2 5PT) write: Recent experience with a patient with advanced cancer and insulin dependent diabetes has brought to our attention the sugar content of Oramorph, a recently introduced formulation of oral morphine sulphate solution. Oramorph is manufactured in two strengths, 10 mg in 5 ml and 100 mg in 5 ml, a...

新しい静脈麻酔薬レミマゾラムは，過鎮静の場合フルマゼニルで拮抗できる調節性の良い全身麻酔薬である．今回，脳室腹腔（VP）シャント機能不全による水頭症が悪化したため，レミマゾラムで麻酔導入しデスフルランとレミフェンタニルで維持した全身麻酔手術を行った．麻酔終了時にレミマゾラムの効果残存を疑いフルマゼニルを投与した直後に，全身性痙攣を生じた症例を経験した．

asperugo procumbents l. has been used in iranian traditional medicine for the refreshing, tranquillizing and mood elevating activities. the present study was undertaken to evaluate the antidepressant and sedative-hypnotic potential of acute administration of the hydroalcoholic extract of this plant in mice.additionally, the effects of flumazenil on the hypnotic activity of the extracts were eva...

Patients with type II Alexander disease have white matter dysplasia, which may cause various symptoms due to nerve conduction impairment. When providing anesthesia a patient disease, careful and patient-specific individualized risk evaluation must be preceded by planning the method of anesthetic drugs. This is first case report who underwent general anesthesia. We performed on 45-year-old male ...

Objective(s):The mechanism of hypothermia action of acetaminophen (APAP) remains unclear even 125 years after its synthesis. Acetaminophen produces hypothermia. The mechanism of this reduction in core body temperature is not clear but evidence shows that it is not dependent on opioid and cannabinoid receptors. Because of strong documents about the roles of GABA and benzodiazepine receptors in h...

intrinsic dose-dependent properties that affect behaviour. At a high dose (50 mg/kg), it is anticonvulsant (Nutt and Cowen, 1982), but at low doses (10 mg /Kg), it has an anxiogenic action (File and Pellow, 1985). Flumazenil crosses the placental barrier and can easily and quickly pass through the blood-brain barrier (Lister, Greenblatt, Abernethy and File, 1984), thus potentially modifying the...