the aim of the present study was to clarify if old n-mri rat, a strain which is easily available in iran and cheap to maintain, is a suitable alternative to those previously reported. in this model, we compared three quantifiable parameters between old and young rats: biochemically, involving measurement of differences in the lipid profile. histologically, the differences of the thickness of th...

objective(s):atherosclerosis is chronic inflammatory process triggered by oxidative stress. oxidative stress can increase hydrogen peroxide (h2o2)level, which induce atherosclerosis through the processes such as formation of perivascular adipose tissue (pvat), foam cells, and atherosclerotic plaque. antioxidant is needed to control negative effects of oxidative stress. one source of antioxidant...

this paper presents an investigation on the effect of temperature and raw material on microstructure of fine cellular foam used as the insulation of coaxial cables. a set up was prepared and used to produce fine cellular foamed insulation. as the physical  blowing agent, butane was used. the effect of temperature on the microstructure of polyethylene (pe) was worth to note. at high temperature,...

1. Abstract 2. Introduction 3. Nature of lipid in foam cells 4. Sources of cholesterol that accumulates in foam cells 5. Significance of foam cell formation 5.1. Trapping lipid in lesions versus removing lipid from lesions 5.2. Alteration of macrophage function 6. The use of cultured macrophages to study foam cell formation 7. In vitro foam cell formation 7.1. Plasma lipoproteins 7.2. Non-lipop...

Beta-migrating very low density lipoproteins (beta--VLDL) and chemically modified low density lipoproteins (LDL), labeled with the fluorescent probe 3,3'-dioctadecylindocarbocyanine (Dil), were used to determine whether foam cells from atherosclerotic lesions have lipoprotein receptors similar to those of macrophages. The advantage of the Dil probe is that it produces a brilliant fluorescence d...

Beta-migrating very low density lipoproteins (R-VLDL) and chemically modified low density lipoproteins (LDL), labeled with the fluorescent probe 3,3-dioctadecylindocarbocyanine (Dil), were used to determine whether foam cells from atherosclerotic lesions have lipoprotein receptors similar to those of macrophages. The advantage of the Dil probe is that it produces a brilliant fluorescence due to...

The purpose of our study was to investigate the expression levels of TREM-1 (triggering receptor expressed on myeloid cells-1) in U937 foam cells and determine whether TREM-1 regulates the production of tumor necrosis factor-alpha and interleukin-8 in these cells. Human U937 cells were incubated with phorbol 12-myristate 13-acetate and then oxidized human low-density lipoprotein to induce foam ...

Interaction of oxidized LDL (OxLDL) with macrophage-derived foam cells is one of the key events in the development and progression of atherosclerosis. To study this interaction, macrophage-derived foam cells were isolated from rabbit atherosclerotic lesions and the expression of scavenger receptors for OxLDL was examined. Atherosclerosis was induced in rabbits by denudation of the large arterie...