CLAUDE BERNARD first showed that sugar is a normal constituent of blood and recognised that glycosuria is, in some manner, dependent upon hyperglyeaemia. Since then a vast literature has accumulated on the subject and though the consensus of opinion favours the view that there is a renal threshold for sugar this view is not, as yet, unanimous. Thus, according to Benedict et al. [1918], urine no...

A modified and improved micromethod for tyrosine determination has been developed. The method is sensitive, economic and applicable for estimation of tyrosine released in enzymatic reactions and in tissue. A range of Folin-Ciocalteu (FC) reagent was used to optimize the conditions for the development of blue color. Thus in 1.5 ml of the assay system, the suitably diluted FC reagent at the final...

The methods elaborated by Folk’ for the determination of small quantities of creatine and creatinine have been of great service in quantitative investigations involving these compounds, and the numerous criticisms and modifications suggested as improvements on the original technique are sufficient, evidence of their widespread use. But recent discussions2s 3, 4 have disclosed several possible s...

The 19th and 20th centuries witnessed the growth and development of clinical chemistry. Many of the individuals and the significance of their contributions are not very well known, especially to new members of the profession. This survey should help familiarize them with the names and significance of the contributions of physicians and chemists such as Fourcroy, Berzelius, Liebig, Prout, Bright...

11 HASSID and ABRAHAM, Chemical Procedures for Analysis of Polysaccharides, in: Methods of Enzymology, Vol . 3, Academic Press, New York 1957. 12 F. W. FALES, J. biol. Chemistry 193, 113 [1951] . 13 N. NELSON and M. SOMOGYI, as cited in Practical clinical B i o c h e m i s t r y , H . V A R L E Y , 4 t h e d i t i o n , W . HEINEMANN, Medical Book Ltd., London 1967. 14 O. FOLIN and H. Wu, as ci...