Pulse-chase labeling of foot-and-mouth disease virus-infected bovine kidney cells revealed stable and unstable viral-specific polypeptides. To identify precursor-product relationships among these polypeptides, antisera against a number of structural and nonstructural viral-specific polypeptides were used. Cell-free translations programmed with foot-and-mouth disease virion RNA or foot-and-mouth...

Int J Vaccines Vaccin 2016, 3(2): 00060 Abbreviations: FMDV: Foot and Mouth Disease Virus; BHK: Baby Hamster Kidney; CPE: Cytopathic Effects; ELISA: Enzyme Linked Immunosorbent Assay; FMD: Foot and Mouth Disease; CFT: Complement Fixation Test, VNT: Virus Neutralization Test; PBS: Phosphate Buffered Saline; IF: Infectious Fluids; OD: Optical Density; BA: Bacteriological Media; ELISA: Enzyme Link...

Foot-and-mouth disease is an extremely infectious and devastating disease affecting all species of cloven-hoofed animals. To understand the epidemiology of the causative virus and predict viral transmission dynamics, quantified transmission parameters are essential to decision makers and modellers alike. However, such quantified parameters are scarcely available, and recently a series of animal...

The Foot-and-Mouth Disease virus (FMDV) is not a public health threat, but it is highly contagious to cloven-footed animals. The virus is shed into milk up to 33 h before there are apparent signs of the disease in dairy cows, and, in extreme cases, signs of disease may not appear for up to 14 d. During this time, raw milk can serve as a vector for spread of the disease both at the farm and duri...

Proposed changes to the International Animal Health Code chapter on foot and mouth disease (FMD) reflect both the introduction of new diagnostic tests to identify animals carrying live FMD virus, and pressure to make more acceptable the use of vaccination to help control outbreaks. It is important that those using the Code fully understand the implications of these changes. One of the proposed ...

Foot and mouth disease (FMD) has devastated the cattle industry in Sri Lanka many times in the past. Despite its seriousness, limited attempts have been made to understand the disease to ameliorate its effects-current recommendation for vaccines being based solely on immunological assessments rather than on molecular identification. The general belief is that the cattle population in Sri Lanka ...

Estimating detailed transmission trees that reflect the relationships between infected individuals or populations during a disease outbreak often provides valuable insights into both the nature of disease transmission and the overall dynamics of the underlying epidemiological process. These trees may be based on epidemiological data that relate to the timing of infection and infectiousness, or ...

We investigated the molecular epidemiology of foot-and-mouth disease virus (FMDV) serotype Asia 1, which caused outbreaks of disease in Asia during 2003-2007. Since 2004, the region affected by outbreaks of this serotype has increased from disease-endemic countries in southern Asia (Afghanistan, India, Iran, Nepal, Pakistan) northward to encompass Kyrgyzstan, Tajikistan, Uzbekistan, several reg...