Two-level factorial and fractional factorial designs have played a prominent role in the theory and practice of experimental design. Though commonly used in industrial experiments to identify the significant effects, it is often undesirable to perform the trials of a factorial design (or, fractional factorial design) in a completely random order. Instead, restrictions are imposed on the randomi...

The aim of this study is to manipulate musical cues systematically to determine the aspects of music that contribute to emotional expression, and whether these cues operate in additive or interactive fashion, and whether the cue levels can be characterized as linear or non-linear. An optimized factorial design was used with six primary musical cues (mode, tempo, dynamics, articulation, timbre, ...

An A-optimal minimax design criterion is proposed to construct fractional factorial designs, which extends the study of the D-optimal minimax design criterion in Lin and Zhou (Canadian Journal of Statistics 41, 325–340, 2013). The resulting Aoptimal and D-optimal minimax designs minimize, respectively, the maximum trace and determinant of the mean squared error matrix of the least squares estim...

An investigator who plans to conduct an experiment with multiple independent variables must decide whether to use a complete or reduced factorial design. This article advocates a resource management perspective on making this decision, in which the investigator seeks a strategic balance between service to scientific objectives and economy. Considerations in making design decisions include wheth...

State University of New York at Stony Brook 2A two-level factorial design can be uniquely represented by a polynomial indicator function. Therefore, properties of factorial designs can be studied through their indicator functions. This paper shows that indicator function is an effective tool in studying two-level factorial designs. Indicator function is used to generalize aberration criterion o...

Herpes simplex virus type 1 (HSV-1) is known to cause diseases of various severities. There is increasing interest to find drug combinations to treat HSV-1 by reducing drug resistance and cytotoxicity. Drug combinations offer potentially higher efficacy and lower individual drug dosage. In this paper, we report a new application of fractional factorial designs to investigate a biological system...

A new class of two-level non-regular fractional factorial designs is defined. We call this class an affinely full-dimensional factorial design, meaning that design points in the design of this class are not contained in any affine hyperplane in the vector space over F2. The property of the indicator function for this class is also clarified. A fractional factorial design in this class has a des...