Cytosolic 10-formyltetrahydrofolate dehydrogenase (FDH, ALDH1L1) is an abundant enzyme of folate metabolism. It converts 10-formyltetrahydrofolate to tetrahydrofolate and CO(2) in an NADP(+)-dependent reaction. We have identified a gene at chromosome locus 12q24.11 of the human genome, the product of which has 74% sequence similarity with cytosolic FDH. This protein has an extra N-terminal sequ...

CLINICALCHEMISTRY, Vol. 34, No. 3, 1988 599 2. Stockigt JR, De Garis M, Barlow JW. “Unbound analog” methods for free T4: a note of caution. N Engi J Med 1982;307:126. 3. De Nayer P, Malvaux P, Beckers C. Familial dysalbuminemic hyperthyroxinemia (FDH): inadequacy of the “analog” methods for assaying free T4 levels. Eur J Nuci Med 1984;9:284-5. 4. Stockigt JR, Dyer SA, Mohr VS. White EL, BarlowJ...

In methylotrophic bacteria, formaldehyde is an important but potentially toxic metabolic intermediate that can be assimilated into biomass or oxidized to yield energy. Previously reported was the purification of an NAD(P)(+)-dependent formaldehyde dehydrogenase (FDH) from the obligate methane-oxidizing methylotroph Methylococcus capsulatus (Bath), presumably important in formaldehyde oxidation,...

This paper is a case report of a 10-year-old girl with focal dermal hypoplasia (FDH) who presented for dental care. She displayed many of the well-documented oral features associated with this syndrome. Additionally, she had taurodontism of a permanent mandibular molar. Although taurodontism affected only one tooth in this patient, the presentation of taurodontism with FDH has not been reported...

Non-oscillatory discretization methods based on the Local Extremum Diminishing principle, which were originally devised for compressible flow, are applied to the free-surface evolution equation. More specifically, both symmetric and upstream limited schemes are utilized in the calculation of the flow about the Series 60 hull, a naval frigate hull with sonar dome and transom stern, and a fully c...

there are different methods to reduce drag in high speed hulls. one of these methods is a change in the shape of the body by adding longitudinal side tunnels. in this paper it has been attempted to determine the influence of the tunnel height on hydrodynamic characteristics of the hull to achieving an optimum shape for the tunnel. to achieve this purpose, numerical simulation of the problem has...

We study an online weighted assignment problem with a set of fixed nodes corresponding to advertisers and online arrival of nodes corresponding to ad impressions. Advertiser a has a contract for n(a) impressions, and each impression has a set of weighted edges to advertisers. The problem is to assign the impressions online so that while each advertiser a gets n(a) impressions, the total weight ...

The familial dysalbuminemic hyperthyroxinemia (FDH) phenotype results from a natural human serum albumin (HSA) mutant with histidine instead of arginine at amino acid position 218. This mutation results in an enhanced affinity for thyroxine. Site-directed mutagenesis and a yeast protein expression system were used to synthesize wild type HSA and FDH HSA as well as several other HSA mutants. Stu...

We present a definition of the four-dimensional helicity (FDH) regularization scheme valid for two or more loops. This scheme was previously defined and utilized at one loop. It amounts to a variation on the standard ’t Hooft-Veltman scheme and is designed to be compatible with the use of helicity states for “observed” particles. It is similar to dimensional reduction in that it maintains an eq...