abstract tuberculosis and diabetes mellitus are the most important reasons in mortality all over the world. it’s clear that reviewing of relationship between tuberculosis (tb) and diabetes mellitus (dm) is necessary; on the other hand it’s found that fto gene has the positive relationship with metabolic issues. therefore, it’s necessary pay attention to the above and dangerous sicknesses, espec...

background: we aimed to elucidate the association between fat mass and obesity associated gene (fto) polymorphism and the risk of polycystic ovary syndrome (pcos) by meta-analysis. methods: we searched pubmed and embase databases to find the relevant studies. odds ratios (ors) and their corresponding 95% confidence intervals (cis) were used for pooled analysis. statistical analyses were carried...

Background: Perilipins are proteins at the external level of the lipid glob in adipocytes steroid-generating cells and play a central role in lipid storage and breakdown. FTO gene is associated with Type-2 diabetes (T2D) and increased fat mass. Association of Perilipin and FTO genes polymorphism with T2D was investigated. Methods: Clinical traits in a random sample of 183 Iranian men and wom...

Abstract Tuberculosis and diabetes mellitus are the most important reasons in mortality all over the world. It’s clear that reviewing of relationship between Tuberculosis (TB) and diabetes mellitus (DM) is necessary; on the other hand it’s found that FTO gene has the positive relationship with metabolic issues. Therefore, it’s necessary pay attention to the above and danger...

Genome-wide association studies have shown that variants in fat mass and obesity-associated (FTO) gene are robustly associated with body mass index and obesity. These FTO variants are also associated with end stage renal disease and all-cause mortality in chronic kidney diseases. However, the exact role of FTO in kidneys is currently unknown. Here we show that FTO expression is increased after ...

Until recently, evidence was lacking for an enhanced gene expression of the fat mass and obesity (FTO) gene in humans who carry obesitysusceptible genetic variants in FTO. By using a data set of 153 cerebellar brain samples from individuals of European ancestry, Smemo and colleagues have now demonstrated that carriers of common single nucleotide polymorphisms in the FTO gene exhibit a higher ce...

The Fto gene was first cloned after identification of a Fused toe (Ft) mutant mouse, whose phenotype arised from a 1.6mb deletion of six genes, including Fto [1, 2]. FTO is a very large gene, also known as fat mass and obesity associated gene. In human, it is located on chromosome 16, consisting of 9 exons and spanning more than 400kb [3]. FTO mRNA is widely expressed in different tissues, espe...

Gene variants of the FTO (fatso) gene have recently been strongly associated with body mass index and obesity. The FTO gene is well conserved and found in a single copy in vertebrate species including fish and chicken, suggesting that the ancestor of this gene was present 450 million years ago. Surprisingly, the FTO gene is present in two species of algae but not in any other invertebrate speci...

INTRODUCTION Placental function is an important determinant of fetal growth, and fetal growth influences obesity risk in childhood and adult life. Here we investigated how FTO and MC4R gene variants linked with obesity relate to patterns of fetal growth and to placental FTO expression. METHODS Southampton Women's Survey children (n = 1990) with measurements of fetal growth from 11 to 34 weeks...

Human FTO gene variants are associated with body mass index and type 2 diabetes. Because the obesity-associated SNPs are intronic, it is unclear whether changes in FTO expression or splicing are the cause of obesity or if regulatory elements within intron 1 influence upstream or downstream genes. We tested the idea that FTO itself is involved in obesity. We show that a dominant point mutation i...