نتایج جستجو برای: furin

تعداد نتایج: 1326  

Journal: :iranian journal of pharmaceutical sciences 0
farzaneh lotfipour faculty of pharmacy, tabriz university of medical sciences, tabriz, iran, diseases of aging program, regional protein chemistry center, ottawa health research institute, university of ottawa, ottawa, ontario, canada, mohammad hossein zarrintan faculty of pharmacy, tabriz university of medical sciences, tabriz, iran, jabraeil sherbafi research center for pharmaceutical nanotechnology, tabriz university of medical sciences, tabriz, iran ajoy basak diseases of aging program, regional protein chemistry center, ottawa health research institute, university of ottawa, ottawa, ontario, canada,

furin is a ca 2+ -dependent serine protease which cleaves proprotein substrates at the arg-xaa-(lys/arg)-arg    site to generate biologically active proteins. furin’s critical role in many cellular events associated with health disorders such as hiv, sars, anthrax, and influenza as well as cancer has made inhibitors of this enzyme as therapeutic targets. to this date, the most potent inhibitor ...

2013
Kai Kappert Heike Meyborg Jan Fritzsche Daniel Urban Janine Krüger Ernst Wellnhofer Ulrich Kintscher Eckart Fleck Philipp Stawowy

BACKGROUND Matrix metalloproteinase (MMP)-dependent extracellular matrix (ECM) remodeling is a key feature in cardiometabolic syndrome-associated adipogenesis and atherosclerosis. Activation of membrane-tethered (MT) 1-MMP depends on furin (PCSK3). However, the regulation and function of the natural furin-inhibitor serpinB8 and thus furin/MT1-MMP-activity in obesity-related tissue inflammation/...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2006
Guan-Sheng Jiao Lynne Cregar Jinzhi Wang Sherri Z Millis Cho Tang Sean O'Malley Alan T Johnson Sina Sareth Jason Larson Gary Thomas

Furin plays a crucial role in embryogenesis and homeostasis and in diseases such as Alzheimer's disease, cancer, and viral and bacterial infections. Thus, inhibition of furin may provide a feasible and promising approach for therapeutic intervention of furin-mediated disease mechanisms. Here, we report on a class of small molecule furin inhibitors based on 2,5-dideoxystreptamine. Derivatization...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2001
M Negishi D Lu Y Q Zhang Y Sawada T Sasaki T Kayo J Ando T Izumi M Kurabayashi I Kojima H Masuda T Takeuchi

Furin, a yeast Kex2-family endoprotease, converts many vasoregulatory propeptides, including pro-transforming growth factor (TGF)-beta to their mature forms. We examined whether furin expression is regulated by shear stress in vivo and in vitro. When an arteriovenous shunt was placed between the carotid artery and external jugular vein in rabbits, furin and TGF-beta were highly expressed in she...

2016
Patricia Jaaks Valentina D’Alessandro Nicole Grob Sina Büel Katarina Hajdin Beat W. Schäfer Michele Bernasconi

The proprotein convertase (PC) furin cleaves precursor proteins, an important step in the activation of many cancer-associated proteins. Substrates of furin and furin-like PCs play a role in proliferation, metastasis and invasion. Some of them are involved in the progression of the pediatric soft tissue sarcoma rhabdomyosarcoma (RMS). In this study, we show that PCs, and in particular furin, ar...

2018
Junko Hasegawa-Minato Masafumi Toyoshima Masumi Ishibashi Xuewei Zhang Shogo Shigeta Carla Grandori Kazuyuki Kitatani Nobuo Yaegashi

c-Myc is a master regulator of various oncogenic functions in many types of human cancers. However, direct c-Myc-targeted therapy has not been successful in the clinic. Here, we explored a novel therapeutic target, which shows synthetic lethality in c-Myc-driven ovarian cancers, and examined the molecular mechanism of the synthetic lethal interaction. By high throughput siRNA screening with a l...

Journal: :Journal of cell science 2008
Jinbo Han Yiguo Wang Suming Wang Chengwu Chi

Furin is a proprotein convertase that cycles between the plasma membrane, endosomes and the trans-Golgi network (TGN), maintaining a predominant distribution in the latter. Mint3, a member of the Mint protein family, is involved in the signaling and trafficking of membrane proteins. Until now, little has been known about the roles of Mint3 in the localization or trafficking of Furin. Here, usin...

Journal: :Journal of neuroscience research 2015
Yan Chen Junjian Zhang Min Deng

This study investigated the changes in brain-derived neurotrophic factor (BDNF) expression and the role of furin in BDNF maturation in reactive astrocytes from rats exposed to oxygen-glucose deprivation (OGD). Furin, a proprotein convertase, is upregulated and cleaves certain substrates during hypoxia in cancer cells. In addition, during hypoxia in the central nervous system, astrocytes become ...

Journal: :Infection and immunity 2004
Miroslav S Sarac Juan R Peinado Stephen H Leppla Iris Lindberg

The anthrax toxin protective antigen precursor is activated by proteolytic cleavage by furin or a furin-like protease. We present here data demonstrating that the small stable furin inhibitor hexa-D-arginine amide delays anthrax toxin-induced toxemia both in cells and in live animals, suggesting that furin inhibition may represent a reasonable avenue for therapeutic intervention in anthrax.

Journal: :The Journal of Cell Biology 1997
Gseping Liu Laurel Thomas Robin A. Warren Caroline A. Enns C. Casey Cunningham John H. Hartwig Gary Thomas

Furin catalyzes the proteolytic maturation of many proproteins within the trans-Golgi network (TGN)/endosomal system. Furin's cytosolic domain (cd) directs both the compartmentalization to and transit between its manifold processing compartments (i.e., TGN/biosynthetic pathway, cell surface, and endosomes). Here we report the identification of the first furin cd sorting protein, ABP-280 (nonmus...

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