Oral fluids are being used as an alternative matrix to urine for drug testing. Oral fluid is considered to be less invasive and much more difficult to adulterate than urine samples. Samples of oral fluid are typically screened by an ELISA immunoassay method. Those found to be positive must be further analyzed with a mass spectrometry confirmation technique. The confirmation technique must be ab...

The purpose of postmortem forensic toxicological analysis is to determine the role of any unknown drug/poison in causing death. The first and the most important step in the analysis scheme is the screening of biological specimens for the presence of drugs/poison. Currently, general unknown screening (GUS) or systemic toxicological analysis (STA) procedure involves gas chromatography-mass spectr...

The complex nature of botanicals and essential oils makes it difficult to identify all of the constituents by gas chromatography/mass spectrometry (GC/MS) alone. In this paper, automated sequential, multidimensional gas chromatography/mass spectrometry (GC-GC/MS) was used to obtain a matrix-specific, retention time/mass spectrometry library of 190 juniper berry oil compounds. GC/MS analysis on ...

A retention-time-locked mass spectral database was created specifically for indoor air analysis by thermal desorption/gas chromatography/mass spectroscopy (TD/GC/MS). This Indoor Air Toxics Database contains locked retention times and mass spectra for 171 volatile and semivolatile organic compounds that are targets in various indoor air methods. In combination with Agilent's Deconvolution Repor...

A series of acylated derivatives of 3,4-methylenedioxy-methamphetamine (3,4-MDMA) are prepared and evaluated in gas chromatography-mass spectrometry (GC-MS) studies. The perfluoroalkyl amides of 3,4-MDMA show the lowest GC retention, while the aromatic amides such as the benzamide show the greatest retention on the dimethylpolysiloxane stationary phase (Rtx-1). The mass spectral properties of t...

This paper discusses the identification of kava lactones and related compounds by gas chromatography (GC) and quadrupole time-of-flight mass spectrometry (QTOFMS) with an electron ionization source. Three herbal preparations from different sources were analyzed by both GC-low-resolution MS and GC-high-resolution MS. The exact mass measurements generated with a research QTOFMS with mass accuraci...

The beneficial effects of alfacalcidol (ALF) on bone mass, bone formation, and bone resorption have been established in ovariectomized rats. Our previous studies showed that high-dose glucocorticoid (GC) administration (methylprednisolone sodium succinate, 5.0 mg/kg, s.c., 3 times a week) for 4 wk induced cancellous osteopenia without significantly affecting cortical bone mass in Sprague-Dawley...