نتایج جستجو برای: genetic association studies

تعداد نتایج: 2288421  

Journal: :genetics in the 3rd millennium 0
reza darvishzadeh ahmad heidari hamid hatami maleki

potato virus y (pvy) is one of the most important pathogenic agents that reduce the yield and quality of tobacco (nicotiana tabacum l.). dna-based molecular markers are valuable tools for identifying germplasm in gene banks, assessing kinship ties, and doing marker-assisted selection (mas) for resistance to pests, diseases, and some crop traits of interest. this work presents the results of ass...

Journal: :iranian red crescent medical journal 0
zi-kai song department of cardiology, the first hospital of jilin university, changchun, china hong-yan cao department of cardiology, the first hospital of jilin university, changchun, china hai-di wu department of cardiology, the first hospital of jilin university, changchun, china li-ting zhou department of occupational and environmental health, school of public health, jilin university, changchun, china ling qin department of cardiology, the first hospital of jilin university, changchun, china; department of cardiology, the first hospital of jilin university, changchun, china. tel: +86-15843073203; fax: +86-043184841049

conclusions rs9364559 in the lpa gene may contribute to the risk of cad in the han chinese population; haplotypes which contain rs9346816-g were all associated with an increased risk of cad in this study. background mutations in the solute carrier family 22 member 3 (slc22a3), lipoprotein (a)-like 2 (lpal2), and the lipoprotein (a) (lpa) gene cluster, which encodes apolipoprotein (a) [apo (a)] ...

Journal: :iranian red crescent medical journal 0
mohammad reza eslami amirabadi behavioral sciences research center, shahid beheshti university of medical sciences, tehran, ir iran sepideh rajezi esfahani behavioral sciences research center, shahid beheshti university of medical sciences, tehran, ir iran rozita davari-ashtiani department of psychiatry, imam hossein hospital, shahid beheshti university of medical sciences, tehran, ir iran mojgan khademi department of psychiatry, imam hossein hospital, shahid beheshti university of medical sciences, tehran, ir iran babak emamalizadeh department of medical genetics, shahid beheshti university of medical sciences, tehran, iran abolfazl movafagh department of medical genetics, shahid beheshti university of medical sciences, tehran, iran

conclusions the obtained results confirm some previous studies regardinga gender specific association of maoa gene with the bipolar disorder. results significant associations were observed regarding maoa-ca (p = 0.016) and maoa-vntr (p = 0.004) polymorphisms in the bipolar females. there was no association between maoa-rflp and bipolar disorder. patients and methods this study is a case-control...

Journal: :anesthesiology and pain medicine 0
mahsa motavaf department of molecular medicine, rezvan medical research institute, iran saeid safari department of molecular medicine, rezvan medical research institute, iran; department of anesthesiology, rasoul akram medical center, iran university of medical sciences (iums), iran seyed moayed alavian department of molecular medicine, rezvan medical research institute, iran; baqiyatallah research center for gastroenterology and liver diseases, baqiyatallah university of medical sciences, iran +98-2188945186, [email protected]; baqiyatallah research center for gastroenterology and liver diseases, baqiyatallah university of medical sciences, iran +98-2188945186, [email protected]

2004
Young Ho Lee

Meta-analysis, a statistical tool for combining results across studies, is becoming popular as a method for resolving discrepancies in genetic association studies. Persistent difficulties in obtaining robust, replicable results in genetic association studies are almost certainly because genetic effects are small, requiring studies with many thousands of subjects to be detected. In this article,...

Journal: :Human heredity 2015
Qi Yan Daniel E Weeks Hemant K Tiwari Nengjun Yi Kui Zhang Guimin Gao Wan-Yu Lin Xiang-Yang Lou Wei Chen Nianjun Liu

OBJECTIVE The kernel machine (KM) test reportedly performs well in the set-based association test of rare variants. Many studies have been conducted to measure phenotypes at multiple time points, but the standard KM methodology has only been available for phenotypes at a single time point. In addition, family-based designs have been widely used in genetic association studies; therefore, the dat...

Journal: :Jornal de pediatria 2008
Andrew Bush

Once upon a time, as all the best children’s stories begin, a lot of clever geneticists began a huge hunt for the “asthma gene.” At first they thought they had found it, but then more andmore of the hunters found different “asthma genes,” and sometimes some gene hunters could not find the gene that previous hunters thoughtwas thekeyone. Life becamemore and more confusing, and the root causes, w...

Journal: :Psychiatry research 2004
Marcus R Munafò Taane G Clark Jonathan Flint

Publication bias may exist when nonsignificant findings remain unpublished, thereby artificially inflating the apparent magnitude of an effect. This concern is not new, but it is particularly current in relation to genetic association studies. Data from a recent meta-analysis of association studies of personality were used to assess the potential of different graphical and statistical methods f...

Journal: :American journal of epidemiology 2008
Wen-Chung Lee Liang-Yi Wang

The case-control study design is popular for genetic association studies of complex human diseases. However, case-control studies may suffer from bias due to population stratification. In this paper, the authors present simple formulas that can set a limit to the havoc population stratification bias can wreak (the lower and upper bounds of the confounding rate ratio and the upper bound of the t...

2016
Wen-Chung Lee

The Cochran-Armitage trend test is a standard procedure in genetic association studies. It is a directed test with high power to detect genetic effects that follow the gene-dosage model. In this paper, the author proposes optimal trend tests for genetic association studies of heterogeneous diseases. Monte-Carlo simulations show that the power gain of the optimal trend tests over the conventiona...

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