background: hepatitis b virus (hbv) gene and protein variations are frequently been seen in chronic patients. the aims of study were to determine the genotypes as well as the patterns of variations distribution in chronically-infected patients from the central part of iran. methods: the surface gene was amplified, sequenced and subsequently aligned using international and national iranian datab...

objective(s) the aim of this study was to characterize the hepatitis b virus surface protein genotypes and sequence variations among hepatitis b virus surface antigen (hbsag) positive chronic patients in hormozgan province, south of iran. materials and methods a total of 8 patients enrolled in this study. the surface gene was amplified and directly sequenced. genotypes and nucleotide/amino acid...

hepatitis c virus (hcv) has chronically infected million peoples worldwide. spontaneous viral clearance occurs in 25% of affected patients.  the standard regimen to treat hcv infection is the combination of pegylated interferon and ribavirin.

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background and aims: chronic hepatitis c is one of the most important etiologies of cirrhosis and hepatocellular carcinoma worldwide. clinical condition of hepatic patients and the outcome of chemotherapy are under impact of hepatitis c virus (hcv) genotypes. therefore, hcv genotyping is important for prediction of success of chemotherapy and progression of liver diseases. methods: in this arti...

Background VEGF gene has been reported to be related with many diseases and recurrent pregnancy loss in various studies. VEGF polymorphisms are risk factors for pregnancy losses, and generally studies report only women’s genetic analyses. To evaluate the association between VEGF A C405G, C460T, C936T and C2578A polymorphisms and spontaneous abortion, we studied the genotypes of spontaneously a...

objectives the aim of this study was to evaluate the efficacy, safety, and tolerability of sofosbuvir and ribavirin in ldlt recipients with recurrent hcv genotype 4. patients and methods thirty-nine egyptian ldlt recipients were treated for recurrent hcv after ldlt with nucleos(t)ide analog ns5b polymerase inhibitor, sofosbuvir, and ribavirin without pegylated interferon for 6 months (november ...

background: this study was conducted to determine of molecular epidemiology of the giardia lamblia by pcr-rflp method in tehran, capital of iran. methods: thirty eight stool samples were randomly selected from 125 patients diagnosed with giardiasis using microscopy in tehran. dna extraction of some samples were performed by phenol/chloroform/isoamyl alcohol method and to raise the sen­sitivity ...