Glucagon and the glucagon receptor are most important molecules control over blood glucose concentrations. These two molecules are very important to studies of type 2 diabetic patients. In literature, several classes of small molecule antagonists of the human glucagon receptor have been reported. Glucagon receptor antagonist could decrease hepatic glucose output and improve glucose control in d...

In order to investigate the relationship between insulin to glucagon ratio and metabolic factors in transitional period of dairy cows, 28 cows heifers with body condition score of 3.25- 3.75 were selected. Dairy cows received close up diet, from 21 days prepartum until parturition and lactation diet according to nutritional requirements after parturition. Blood was sampled at 10 days before and...

Glucagon and the glucagon receptor are most important molecules control over blood glucose concentrations. These two molecules are very important to studies of type 2 diabetic patients. In literature, several classes of small molecule antagonists of the human glucagon receptor have been reported. Glucagon receptor antagonist could decrease hepatic glucose output and improve glucose control in d...

the effects of steroid hormones, glucagon and insulin on rat liver phosphatidate phosphohydrolase (pap) activity were studied both in vitro and in vivo. incubation of rat hepatocytes with each hormone showed that dehydroepiandrosterone (dhea), progesterone and testosterone increase pap activity by 44.6, 37 and 36.9%, respectively. estradiol, however, decreased enzyme activity by 13.6% under the...

Glucagon antagonism has been reported as a new therapeutic approach to hyperglycaemia. As the 14-3-3 protein YWHAB identified regulator of glucagon receptor (GCGR) by affinity purification and mass spectrometry, we examined role in vivo. Ywhab knockout mice display impaired blood glucose homeostasis only under pyruvate stimulation. Deletion mouse primary hepatocytes (MPHs) increases hepatocyte ...

In this work, a novel insulin-glucagon-glucose model is proposed, where the glucagon effect on endogenous glucose production (EGP) described by dynamics of receptors. order to assess quality model, its parameters are fitted in such way that influence EGP isolated. Experimental data used validate structure and show receptor allow explain some glucagon-related phenomena observed clinical data. Th...

Glucagon-like peptide-1 (GLP-1) promotes insulin secretion, inhibits glucagon and repairs pancreatic islet cell function to enhance proliferation regeneration. Furthermore, it includes a mechanism for weight loss angiocarpy protection. This study covers the comparison of GLP-1 agonists with DPP-4 inhibitors GLT-2 inhibitors, agonists, its research possibilities based on summary current clinical...

Glucagon has been shown effective for the treatment of insulinoma-associated hypoglycemia. However, its use limited to preoperative supportive care and emergency hypoglycemic crisis because need constant intravenous infusion administration. Here, we report a case insulinoma in dog managed with subcutaneous saline-diluted glucagon continuous glucose monitoring system (CGMS), which were glycemic ...

background and aims: artichoke (cynara scolymus l.) is a plant of the asteraceae family. this plant is used in herbal medicine. this study was conducted to evaluate the effect of artichokeextract on insulin, glucagon, glucose, alkaline phosphatase (alp), alanine amino transferase (alt) and aspartate amino transferase (ast) in streptozotocin-induced diabetic rats. methods: in this experimental s...

The effects of steroid hormones, glucagon and insulin on rat liver phosphatidate phosphohydrolase (PAP) activity were studied both in vitro and in vivo. Incubation of rat hepatocytes with each hormone showed that dehydroepiandrosterone (DHEA), progesterone and testosterone increase PAP activity by 44.6, 37 and 36.9%, respectively. Estradiol, however, decreased enzyme activity by 13.6% under...