introduction: the development of an effective vaccine against hepatitis c virus (hcv) is still a target of intensive vaccine research. the hcv envelope proteins e1 and e2 which can induce broadly neutralizing antibodies are the major candidate for this purpose. different types of expression systems have been used to express these glycoproteins. in this study, an expression system using pichia p...

The quality of proteins destined for the secretory pathway is ensured by two distinct mechanisms in endoplasmic reticulum (ER): productive folding newly synthesized proteins, which assisted ER-localized molecular chaperones and most cases also disulfide bond formation transfer an oligosaccharide unit; ER-associated degradation (ERAD), unfolded or misfolded ER are recognized processed delivery t...

l-fucose (6.deoxy. l.galactose) is the only monosacharide which is placed in non reducting position of glycoproteins structure in l-deoxy form. l-fucosidase and fucosy 1 transferase directly take part in the elevation or decrease of sorum l-fucose levels. tumors may directly induce enzymes that release l-fucose from glycoproteins formed in the neoplastic tissue, or the glycoproteins may be rele...

Introduction: The development of an effective vaccine against Hepatitis C virus (HCV) is still a target of intensive vaccine research. The HCV envelope proteins E1 and E2 which can induce broadly neutralizing antibodies are the major candidate for this purpose. Different types of expression systems have been used to express these glycoproteins. In this study, an expression system using Pichia p...

Arabinogalactan proteins (AGPs) encompass a diverse group of plant cell wall proteoglycans, which play an essential role in development, signaling, plant-microbe interactions, and many others. Although they are widely distributed throughout the kingdom extensively studied, remain largely unexplored lower plants, especially seaweeds. Ulva species have high economic potential since various applic...

This study examines the mechanism utilized by different MARCH proteins to restrict retrovirus infection. block incorporation of envelope glycoproteins budding virions.

Metastasis describes the ability of a tumor to invade normal tissue and generate secondary tumors at sites distant from the primary tumor. The mechanism responsible for the inhibition of tumor metastasis by different agents is at least partly associated with the ability to interfere with cellular functions such as adhesiveness, motility and invasiveness. Certainly effective treatment of metasta...