The present study uses multivariate pattern classification analysis to examine maturation in task-induced brain activation and in functional connectivity during adolescence. The multivariate approach allowed accurate discrimination of adolescent boys of respectively 13, 17 and 21years old based on brain activation during a gonogo task, whereas the univariate statistical analyses showed no or on...

BACKGROUND Aerobic endurance exercise has been shown to improve higher cognitive functions such as executive control in healthy subjects. We tested the hypothesis that a 30-minute individually customized endurance exercise program has the potential to enhance executive functions in patients with major depressive disorder. METHOD In a randomized within-subject study design, 24 patients with DS...

The executive functions have been studied separately in the fields of neuropsychology and of motor control. However, it is not clear whether across fields one is referring to similar cognitive functions. In the present study, we compared the performance scores obtained in a motor spatial-tapping task with those scores obtained in a battery of three neuropsychological tasks which assess respecti...

During the last decade, repetitive transcranial magnetic stimulation (rTMS) of the prefrontal cortex has become established as a treatment for various mental diseases. The rational of prefrontal stimulation has been adapted from the mode of action known from rTMS using motor-evoked potentials though little is known about the precise effect of rTMS at prefrontal sites. The objective of the curre...