The 2-thiouridine (S2U) unit in the RNA strand is predominantly desulfured with H(2)O(2) to 4-pyrimidinone nucleoside (H2U). The resulting H2U-RNA exhibits significantly lower binding affinity to its complementary strand and in certain conditions undergoes strand scission. These results may explain the tRNA loss of biological function in oxidative stress conditions.

2-Thiouracil-containing nucleosides are essential modified units of natural and synthetic nucleic acids. In particular, the 5-substituted-2-thiouridines (S2Us) present in tRNA play an important role in tuning the translation process through codon-anticodon interactions. The enhanced thermodynamic stability of S2U-containing RNA duplexes and the preferred S2U-A versus S2U-G base pairing are appr...

The paper concerns the weak differentiability of solutions to two kinds nonuniform nonlinear degenerate elliptic systems under p,q-growth condition on Heisenberg Group. We use iteration fractional difference quotients Group get solution u in vertical direction (i.e., Lp(1<p<4) integrability Tu) and then second order horizontal directions L2 ∇H2u) gradient T∇Hu)).

We propose a new method based on the invariant properties of the ansatz of the Hirota method whcih have been discovered recently. This method allows one to construct new solutions for a certain class the dissipative equations classified by degrees of homogeneity. This algorithm is similar to the method of “dressing” the solutions of integrable equations. A class of new solutions is constructed....

This work presents an investigation on phase equilibria in partially miscible systems comprised of water, esters, and alkanols. Experimental liquid–liquid (LLE) were determined for ternaries water+H2u–1Cu–1CO2CvH2v+1+CwH2w+1(OH) (u = 3,4; v 2,3; w 1–4) at 298.15 K the four corresponding water+ester binaries, temperature interval T [283–328] K. The results reveal a complex behavior ternary LLE. ...