The effect of haematocrit on the sequelae of carotid occlusion has been studied in the gerbil stroke model. In 72 animals one carotid artery was clipped. After 30 minutes, the area of cerebral hemisphere filling with a carbon suspension administered intravenously was measured on coronal brain slices and related to the haematocrit. Exchange transfusion of autologous packed red blood cells or pla...

BACKGROUND Artemisinin-based combination treatments (ACTs) or intravenous artesunate are used in over 100 countries for uncomplicated or severe falciparum malaria. Although intravenous artesunate may cause delayed haemolytic anaemia, there is little evaluation of the temporal changes in haematocrit following ACTs. METHODS Clinical and parasitological parameters were measured before and follow...

BACKGROUND In severe malaria, intravenous artesunate may cause delayed haemolytic anaemia but there has been little evaluation of the propensity of oral artemisinin-based combination treatments (ACTs) to cause late-appearing anaemia. METHODS The frequency of anaemia (haematocrit <30%), and temporal changes in haematocrit were evaluated in 1,191 malarious children following ACTs. "Haematocrit ...

1. Anaemia has been reported in wild animals, typically associated with traumatic events or ill health. However, female birds routinely become ‘anaemic’ during egglaying; we sought to determine the causes of this reduction in haematocrit. 2. Haematocrit in female European Starlings ( Sturnus vulgaris Linnaeus) decreased between pre-breeding and egg-laying in 3 out of 4 years (the decrease was m...

BACKGROUND Artemisinin-based combination therapies (ACTs) have remained efficacious treatments of acute falciparum malaria in many endemic areas but there is little evaluation of factors contributing to the anaemia of acute falciparum malaria following long term adoption of ACTs as first-line antimalarials in African children. METHODS Malarious <5 year-olds randomized to artemether-lumefantri...

We compared the blood thixotropic/shear-thinning properties and the red blood cells' (RBC) rheological properties between a group of patients with sickle cell anaemia (SS) and healthy individuals (AA). Blood thixotropy was determined by measuring blood viscosity with a capillary viscometer using a "loop" protocol: the shear rate started at 1 s-1 and increased progressively to 922 s-1 and then r...

Changes in haematocrit in patients with acute myocardial infarction are the subject of several reports. Burch and DePasquale (1962) and DePasquale and Burch (1963) suggested that the peripheral venous haematocrit was raised in acute myocardial infarction. This was not confirmed by subsequent studies (Conley et al., 1964; Vuopio and Eisalo, 1964) but has recently been supported (Stables et al., ...