Elevated circulating homocysteine (Hcy) has been proposed to be associated with non-alcoholic fatty liver disease (NAFLD). It is also reported that Hcy causes protein misfolding in the endoplasmic reticulum (ER). In this study, we used a high methionine diet (HMD)-fed mouse model and cultured primary hepatocytes to investigate the effects of Hcy on hepatic lipids metabolism. C57BL/6J mice recei...

The epithelial cells that line the renal proximal tubule have been shown to be the primary cellular targets where mercuric ions gain entry, accumulate, and induce pathologic effects in vivo. Recent data have implicated at least one of the organic anion transport systems in the basolateral uptake of inorganic mercury (Hg). With the use of a line of type II MDCK cells transfected stably with the ...

See article by Riksen et al. [8] (pages 271–276) in this reaction equilibrium will shift toward AdoHcy production issue. and simultaneously tend to lower the free Ado concenBased on epidemiological studies, homocysteine (Hcy) tration. Riksen and colleagues argue that because Ado has is regarded as an independent risk indicator for occlusive several well known, protective actions in the cardiova...

Introduction: Silymarine extract is currently prescribed by some physicians for treatment of fatty liver disease. In the present study, the effect of administration of tablet containing silymarine extract on plasma homocysteine (Hcy), folate, vitamin B12 and liver enzymes activity in non-alcoholic steatohepatitis (NASH) was investigated. Materials and Methods: Seventy-four patients (40 female a...

Here, we assess the association between homocysteine (Hcy) serum levels and periodontal status in a large representative sample of National Health Nutrition Examination Survey (NHANES). Using 2001–2002 2003–2004 NHANES databases, participants with examination, medical self-reported data, blood pressure (BP) samples to determine complete count, C-reactive protein (CRP) Hcy levels. We then calcul...

A label-free molecularly imprinted electrochemical sensor (MIECS) based on electropolymerized polymer (MIP) was developed for the determination of homocysteine (Hcy) in serum first time. MXene@AuNPs with layered structure synthesized electrode by modifying MXene gold nanoparticles (AuNPs). MIP dopamine hydrochloride (DA) were onto surface modified molecular docking and quantum chemical calculat...

AIMS Various studies have shown that plasma homocysteine (HCY) serum levels are elevated in actively drinking alcohol-dependent patients a during alcohol withdrawal, while rapidly declining during abstinence. Hyperhomocysteinemia has been associated not only with blood alcohol concentration (BAC), but also with deficiency of different B-vitamins, particularly folate, pyridoxine and cobalamin. ...

Hyperhomocysteinaemia is considered as an important independent risk factor for atherosclerosis and thrombotic disease. This study determined the distribution of homocysteine (Hcy) levels in healthy Tunisian subjects and evaluated the relationship between Hcy levels and some cardiovascular risk factors. Randomly selected subjects (592 men and 114 women) were recruited from different regions of ...

SAH after blood sample incubation over a period of 0, 2, 6, and 24 h at room temperature or at 4 °C. In the Primavette, Hcy obtained by HPLC decreased only slightly (Ϫ4.8%) after 6-h incubation at room temperature and returned to the baseline value after 24 h. At 4 °C a significant decrease of Hcy (6.9%) after 24-h incubation was found (P ϭ 0.003). Applying FPIA for the determination of Hcy, no...

There is now growing evidence supporting the association between renal insufficiency and accumulation of plasma homocysteine (Hcy). However, the role of Hcy in the development of diabetic nephropathy (DN) in type 2 diabetic patients is not clearly elucidated. To this end, we performed a prospective observational study in 208 patients and 49 controls. We show that baseline level of Hcy is signif...