extramedullary hematopoiesis is characterized by the presence of hematopoietic tissue outside the bone marrow. extrathoracic extramedullary hematopoiesis is a rare and usually asymptomatic condition. we report a case of a 38-year-old female with paraspinal and presacral extramedullary hematopoiesis with polycythemia vera. clinical and laboratory evaluation, along with radiological and histopath...

spinal cord compression due to extramedullary hematopoiesis is a well-described and rare syndrome encountered in several hematological disorders including β-thalassemia. hereby, a 37-year old pregnant woman with intermediate β -thalassemia with paraparesis and lower limb hypoesthesia was presented. mri showed soft tissue masses in both sides of thoracic paraspinal area. histologically, a mixtur...

introduction extramedullary hematopoiesis in the kidney and adrenal are rarely reported in medical literature and are usually found as incidentaloma. it usually occurs in patients with hematologic disorder such as thalassemia. case presentation the patient was a 23-year-old iranian man with beta thalassemia who was admitted with a suprarenal mass. adrenal mass was detected by ultrasonography an...

Impaired hematopoiesis is a serious complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Bone marrow aplasia and peripheral cytopenias arise from primary secondary graft failure or poor function. Chimerism analysis useful to discriminate these conditions. By determining the pathogenesis of impaired hematopoiesis, timely appropriate treatment can be performed. Hemat...

We developed here a new mathematical modelling approach which reconciliates native and stress hematopoiesis, focused on hematopoietic stem progenitor compartments. first proposed an erythropoiesis model leaning minimum of 6 cell-amplification compartments, able to reproduce erythropoiesis. A phenylhydrazine-induced hemolytic was next applied, and in vivo data were used estimate parameters throu...

Blood development proceeds through several waves of hematopoietic progenitors with unclear lineage relationships, which convolute the understanding process. Thinking precursors as “blood germ layer” can integrate these into a unified that originates in yolk sac, earliest site blood development. Hematopoietic differentiation pluripotent stem cells (PSCs) reflects to certain extent complexities s...

background: interferon beta-la and -1b have been increasingly used for the treatment of multiple sclerosis (ms). the most frequent systemic adverse effects are flu-like symptoms. laboratory abnormalities include asymptomatic leukopenia and elevated hepatic transaminases. myelodysplastic syndrome (mds) refers to a spectrum of hematological disorders which can occur in different situations. sever...

The objective of the research was to study histological peculiarities spleen structure East European hedgehog (Erinaceus concolor Linnaeus, 1758) in postnatal ontogenesis. For our investigation, 5 animals each age group were selected; so 20 hedgehogs studied order determine extramedullary hematopoiesis. Terminology described structures used compliance with International Histological Nomenclatur...