Background and objectives: Viola odorata L. is a grassy plant that grows in the humid regions and has been used to treat liver diseases and complicated and tropical fevers in Iranian traditional medicine (ITM). V. odorata has cold and humid temperament while the temperament of fever which is the most important symptom of malaria is the opposite. Antimalarial a...

We have investigated the contribution of drug accumulation and inhibition of heme polymerization to the in vitro activities of a series of antimalarial drugs. Only those compounds exhibiting structural relatedness to the quinolines inhibited heme polymerization. We could find no direct correlation between in vitro activity against chloroquine-susceptible or chloroquine-resistant isolates and ei...

The population at risk of developing malaria in the Asian region is 1.4 billion people. Nine countries are high where highest proportion achieved by India 89%, Myanmar 2% and Indonesia 7%. Inhibition heme polymerization an initial screening test for antimalarial activity. Bidara leaves (Ziziphus mauritiana L.) were selected based on content secondary metabolites containing alkaloids. Plant comp...

Heme is a compound consisting of an iron (Fe) atom bound to pyrrole ring forming protoporphyrin IX (PPIX). Protoporphyrin combines with protein-forming hemoprotein that plays essential role in oxygen-binding and transport as well the process energy production mitochondria. Some cancer cells have more heme biosynthesis than normal cells, which thought be linked cell growth. Inhibition some leads...

Endoperoxide antimalarials based on the ancient Chinese drug Qinghaosu (artemisinin) are currently our major hope in the fight against drug-resistant malaria. Rational drug design based on artemisinin and its analogues is slow as the mechanism of action of these antimalarials is not clear. Here we report that these drugs, at least in part, exert their effect by interfering with the plasmodial h...

up-regulation of cd4+cd25+cd127low/- regulatory t cells (tregs) is a new target in the treatment of asthma. human bone marrow mesenchymal stem cells can up-regulate cd4+cd25+cd127low/- regulatory t cells in vitro,  meanwhile, heme oxygenase-1 (ho-1) plays an important role in the development and maintenance of cd4+cd25+ regulatory t cells. however the mechanism has not yet been adequately under...

The human parasite Plasmodium falciparum enzymatically digests hemoglobin during its intra-erythrocytic developmental stages in acidic food vacuole compartments. The released heme is rapidly detoxified by polymerization into the chemically inert pigment, hemozoin. Several heme-binding anti-malarial compounds, such as chloroquine, efficiently inhibit this process, and this is believed to be the ...

The aim of this study was to analyze the effect heme synthesis inhibition on cytoglobin expression and its correlation with keloid fibroblast viability proliferation. conducted primary culture fibroblasts. Heme in fibroblasts inhibited using succinyl acetone. We measured ALAD enzyme activity a colorimetric method; mRNA qRT-PCR; protein ELISA immunocytochemistry; MTT test; proliferation BrdU tes...