نتایج جستجو برای: hemin

تعداد نتایج: 1643  

ژورنال: Medical Laboratory Journal 2007
Alavi, A, Ghadiri, A, Hadizadeh, F, Mirkheshti, N, Moradi, Sh,

Abstract Background and objectives: Hemin is a porphyrin compound derived from hemoglobin, the precursor of other porphyrin hemoglobin derivatives and the raw material of Hematin. Since hemin is widely used in medicine, we decided primarily to synthesize this substance in Laboratory and to determine the best way of hemin extraction from untransfused and expired blood units. Materials and Method...

Background: Hemin is an important sterile component that induces a neuroinflammatory response after intracerebral hemorrhage, in which NLRP3 inflammasome activation has also proved to be involved. Although microglial activation acts as a key contributor in the neuroinflammatory response, the relationship between hemin and NLRP3 in microglia remains poorly understood. Objective: To investigate w...

Journal: :Infection and immunity 1994
C A Genco B M Odusanya G Brown

Although hemin is an essential nutrient for the black-pigmented oral bacterium Porphyromonas gingivalis, the mechanisms involved in hemin binding and uptake are poorly defined. In this study, we have examined the binding of hemin and Congo red (CR) to P. gingivalis whole cells and have defined the conditions for maximal binding. Additionally, the accumulation of hemin by P. gingivalis under gro...

Journal: :Chemical communications 2015
Gui-Xia Wang Yue Zhou Min Wang Wen-Jing Bao Kang Wang Xing-Hua Xia

We propose a strategy to control directly the orientation of hemin plane via experimental models, Hemin-His model and Hemin-MHN model with ODT. Electrochemical results show that electron communication is largely enhanced when the hemin plane is near to parallel to the electrode surface by histidine ligation in Hemin-His model, while the electron transport of hemin in Hemin-MHN model with ODT be...

Journal: :Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2008
Christen Seaman Joseph Moritz Elizabeth Falkenstein Knox Van Dyke Giovanni Casotti Hillar Klandorf

The objective of these studies was to determine whether inosine, a precursor of the antioxidant uric acid, can ameliorate hemin-induced oxidative stress. Dietary inclusion of inosine was begun either before or after hemin-induced oxidative stress. Broilers (4 weeks) were divided into four treatment groups (Control, Hemin, Inosine, Hemin/Inosine). Throughout the study control birds (n=10) were i...

Under prolonged diabetic conditions, HbA1c is produced from normal hemoglobin (HbA0) through a non-enzymatic glycosylation or glycation, a process which enhances the hemoglobin susceptibility to be auto-oxidized to methemoglobin (metHb). Here we are reporting that the non-enzymatic reaction between fructose and metHb (metHb fructation) induces significant changes in the gl...

Journal: :The Journal of biological chemistry 2010
Fang Yang Xian Xia Hui-Yan Lei En-Duo Wang

The free form of human cytoplasmic arginyl-tRNA synthetase (hcArgRS) is hypothesized to participate in ubiquitin-dependent protein degradation by offering arginyl-tRNA(Arg) to arginyl-tRNA transferase (ATE1). We investigated the effect of hemin on hcArgRS based on the fact that hemin regulates several critical proteins in the "N-end rule" protein degradation pathway. Extensive biochemical evide...

Journal: :The Journal of biological chemistry 1980
J D Etlinger A L Goldberg

Previous studies have established that hemin stimulates production of globin and other proteins in reticulocytes and nonerythroid cells. Such studies generally equated increased production with more rapid synthesis and ignored the additional possibility that hemin decreases protein degradation. Addition of hemin to cell-free extracts of rabbit reticulocytes consistently inhibited the rapid ATP-...

2002
David L. Compton Joseph A. Laszlo

The direct electrochemical reduction of hemin, protoporphyrin(IX) iron(III) chloride, ligated with strong or weak heterocyclic bases, was investigated in the ionic liquids (IL), 1-butyl-3-methylimidazolium hexafluorophosphate ([bmim][PF6]) and 1-octyl-3methylimidazolium hexafluorophosphate ([omim][PF6]), using cyclic voltammetry and chronocoulometry. Hemin complexed with N-methylimidazole (NMI)...

Journal: :Nihon Hinyokika Gakkai zasshi. The japanese journal of urology 1994
A Tsuji

Hemin, which is the mitogenic oxidizing agent, has immunostinulatory properties for murine splenocytes. We studied the anti-tumor effect of hemin with IL-2 by using murine renal cell carcinoma (Renca). Treatment of cells with hemin and IL-2 resulted in a marked enhancement of mitogenicity and generation of cytotoxicity in vitro. These enhancements were achieved at low dose of IL-2. Splenocytes ...

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