For the development of novel hepatoprotective agents, C2, C3, C23 and C28 functional groups on asiatic acid were modified, and the prepared compounds were evaluated for their hepatoprotective effects. Among the prepared compounds, 9, 13 and 16 showed significant hepatoprotective activities against CCl4and galactosamine (GaIN)-induced hepatotoxicity. Especially, compound 9 showed the most signif...

For the development of novel hepatoprotective agents, C11, C28, C2,3,23 or C2,23,28 functional groups on asiatic acid were modified, and their hepatoprotective effects were evaluated. Most of the prepared compounds displayed potent hepatoprotective activities against CCl4and galactosamine (GaIN)-induced hepatotoxicity. Especially, compounds 16 and 20 showed the most significant hepatoprotective...

BACKGROUND The effectiveness of hepatoprotective drugs for DIH (drug induced hepatotoxicity) during tuberculosis treatment is not clear. We evaluated the effectiveness of hepatoprotective drugs by comparing the period until the normalization of hepatic enzymes between patients who were prescribed with the hepatoprotective drugs after DIH was occurred and patients who were not prescribed with th...

The protective effects of oleanolic acid-type saponins and their derivatives on in vitro immunological liver injury of primary cultured rat hepatocytes were studied. A known antihepatotoxic saponin (chikusetsusaponin IVa, 1) showed hepatoprotective activity in this model. Although a rhamnosyl derivative (2) of 1 similarly showed hepatoprotective activity, its prosapogenin (5) did not show any h...

Drugs and some chemical agents are known to induce hepatotoxicity in humans which is of great concern to clinicians. Chemical agents are been screen daily for their hepatoprotective properties. Among these chemical agents is vitamin E which has drawn wide attention due to it reported hepatoprotective property as reported by researchers. This study collected and evaluated reports to ascertain th...

homalium letestui pellegr (flacourtiaceae) is used traditionally by the ibibios of southern nigeria to treat stomach ulcer, malaria and other inflammatory diseases and yorubas of western nigeria as an antidote. the hepatoprotective effect of the stem extract (200-600 mg/kg) was evaluated by the assay of liver function parameters, namely total and direct bilirubin, serum protein and albumin, tot...

CONTEXT To systematically evaluate the effects of hepatoprotective agents, when delivered either alone or in combination with other antiviral or non-antiviral drugs in patients with hepatitis B and hepatic fibrosis. OBJECTIVES The current randomized controlled clinical trials aimed to evaluate the efficacy of combinations of antiviral and non-antiviral hepatoprotective agents on indexes of li...

Renal function tests (serum creatinine, urea and uric acid), were performed in acetaminophen-intoxicated rabbits during hepatoprotective and hepatocurative treatment with Momordica charantia fruit extract. In hepatocurative group, the M. charantia treatment was preceded by acetaminophen intoxication, whereas, in hepatoprotective group, the acetaminophen intoxication was preceded by M. charantia...

The present study was carried out to evaluate the hepatoprotective role of leaf extracts of Azadirachta indica A. Juss. Hepatoprotective activities of ethanolic and aqueous extracts of A. indica were examined against carbon tetrachloride induced liver damage in mice using silymarin as control. Enzyme activities of Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum Glutamate Pyruvate Transa...