Hepatic diseases are serious health issues as various pharmaceuticals, xenobiotics, environmental/chemical pollutants, some natural products and dietary supplements when used in overdose have tendency to cause hepatotoxicity. Present study was aimed at investigating hepatoprotective activity of aqueous methanolic extract of Euphorbia prostrata against paracetamol and carbon tetrachloride induce...

The present study was conducted to evaluate the hepatoprotective activity of methanolic extract of aerial parts of Plumbago zeylanica in CCl4-induced hepatotoxicity in wistar rats. Silymarin (100mg/kg, p.o.) was given as reference drug. The extract of aerial parts of Plumbago zeylanica have shown very significant hepatoprotection against CCl4-induced hepatotoxicity in wistar rats by reducing se...

BACKGROUND AND OBJECTIVE Picroliv, isolated from the root and rhizome of Picrorhiza kurroa, is known to have significant hepatoprotective activity. Its effects against Entamoeba histolytica induced liver damage are not studied. This study aims to evaluate the hepatoprotective action of picroliv against the hepatotoxic changes induced by carbon tetrachloride (CCl(4)) and E. histolytica infection...

Silymarin, a known extract, is used in the treatment of liver diseases with various origins, but its current administration form cannot target the liver because of its poor oral bioavailability. A new type of oral silymarin proliposome aimed at improving silymarin's poor bioavailability and hepatoprotective effects, is introduced in this work. Silymarin-loaded liquid proliposome were prepared u...

To investigate the hepatoprotective potential of ethanolinc grape seed extract on acetaminophen (APAP) induced liver toxicity in wistar rats. Silymarin was used as reference hepatoprotective agent. Liver injury was induced by APAP (2 gm/kg body weight, bw) on the 1st day of experiment. Vitis vinifera (V. vinifera)L seed extract (200 and 400 mg/kg bw) and silymarin (100 mg/ kg bw) was administer...

METHODS The study was designed to evaluate the hepatoprotective activity of aqueous extract of central stem of Musa sapientum (AqMS) against carbon tetrachloride induced hepatotoxicity in rats. Animals were divided into six groups. Group I served as normal control. Group II, III, IV, V & VI were administered CCl(4) mixed with olive oil 1:1 (1.5 mL/kg) I.P., twice a week for 5 weeks. Group II wa...

The present study was conducted to evaluate the hepatoprotective activity of ethanolic leaf extract of Couroupita guianensis against CCL4 induced liver damage in rats. Anti-oxidant activity was evaluated by DPPH (2, 2-diphenyl-1-picrylhydrazyl) and hydrogen peroxide scavenging. Ascorbic acid was used as the standard antioxidants for comparison. Healthy male Wistar albino rats of either sex (150...

Oral pre-treatment with ethanolic extract of the roots of C. carandas (ERCC; 100, 200 and 400 mg/kg, po) showed significant hepatoprotective activity against CCl4 and paracetamol induced hepatotoxicity by decreasing the activities of serum marker enzymes, bilirubin and lipid peroxidation, and significant increase in the levels of uric acid, glutathione, super oxide dismutase, catalase and prote...

Medicinal herbs are significant source of pharmaceutical drugs. Latest trends have shown increasing demand of phytodrugs and some medicinal herbs have proven hepatotprotective potential. Silymarin, a flavonol lignan mixture) extracted from the Silybum marianum (milk thistle) is a popular remedy for hepatic diseases. Today every herbal company is marketing formulations for liver disorders but th...

Inula cappa is well known for its medicinal properties like anti-inflammatory, digestive, depurative, carminative, analgesics, antipyretics, treatment of peptic ulcer etc. The present study focuses on the ability of I. cappa to alleviate liver damage caused by over carbon tetrachloride. The aqueous extract of whole plant of I. cappa (400 mg/kg, p.o) significantly showed hepatoprotective activit...