OBJECTIVE To evaluate the hepatoprotective potential of Hepax, a polyherbal formulation, against three experimentally induced hepatotoxicity models in rats. METHODS Hepatoprotective activity of Hepax was studied against three experimentally induced hepatotoxicity models, namely, carbon tetrachloride (CCl4), paracetamol and thiocetamide induced hepatotoxicity in rats. RESULTS Administration ...

OBJECTIVE Recent studies show that free radicals are important mediators of hepatic injury induced by carbon tetrachloride. Allium (A.) paradoxum showed antioxidant and antihemolytic activities. This work was conduct to determine the possible protective effect of this plant against hepatotoxicity. MATERIALS AND METHODS Subcutaneous injection of 3 ml/kg carbon tetrachloride diluted in olive oi...

A comparison of analysis in evaluating the hepatoprotective action of ethanolic extract of M. azedarach (MAE) and P. longum (PLE) with their combination biherbal extract (BHE) against carbon tetrachloride (CCl4) induced hepatic damage is reported in albino rats. There was a marked elevation of serum marker enzyme levels in CCl4 treated rats, which were restored towards normalization in the drug...

hepatoprotective efficacy of propolis extract (honeybee hive product, 200 mg/kg, p.o.) was studied against carbon-tetrachloride-(ccl 4, 0.15 ml/kg, i.p.) induced biochemical and histopathological changes. silymarin, a known hepatoprotective drug was used as a positive control. subchronic exposure to ccl 4 for 3 weeks (5 days a week) caused sharp elevation in the activity of liver enzymes i.e. ,...

Swertia mussotii Franch. (SM) (Gentianaceae) was a traditional Tibetan folk herb for hepatitis in the Qinghai-Tibet plateau areas. For understanding the hepatoprotection and toxicity characteristics of Swertia mussotii Franch., the whole plant of Swertia mussotii was extracted by water (SME-b) and 75% ethanol (SME-a); then, SME-a was dissolved with water, the supernatant was SME-c, and the sedi...

Mung bean is a hepatoprotective agent in dietary supplements. Fermentation and germination processes are well recognized to enhance the nutritional values especially the concentration of active compounds such as amino acids and GABA of various foods. In this study, antioxidant and hepatoprotective effects of freeze-dried mung bean and amino-acid- and GABA-enriched germinated and fermented mung ...

Thespesia lampas (Cav.) Dalz & Gibs an important folk medicinal plant was evaluated for hepatoprotective and antioxidant activity against carbon tetrachloride (CCl4) induced hepatic damage in rats. In the present study, the T. lampas stems extracts at dose of 200 mg/kg body wt. were administered orally once daily for nine days and on seventh day after one hour of drug administration CCl4 (1ml/k...

Cuscuta seeds and whole plant have been used to nourish the liver and kidney. This study was aimed to investigate the hepatoprotective activity of the ethanol extract of Cuscuta campestris Yunck. whole plant (CCEtOH). The hepatoprotective effect of CCEtOH (20, 100 and 500 mg/kg) was evaluated on carbon tetrachloride (CCl₄)-induced chronic liver injury. Serum alanine aminotransferase, aspartate ...

Introduction: Acacia catechu is a deciduous, thorny tree which grows up to 12-15 meter in height. In Hindi is called as Khair and in kannada Kachu. It has been used as used for the treatment of inflammation, diarrhheoa, fever. Aims: to evaluate the hepatoprotective effect of ethanolic extract of acacia catechu in paracetemol induced liver damage in experimental animals, rats was studied. Method...

Dysregulations of cytochromes P450 (P450s) under liver injury have been extensively studied. However, little is known about the possible reversing effects of hepatoprotective agents, the understanding of which is of great importance in guiding clinical dosage adjustment for patients with liver injury. This study aims to investigate the dysregulation patterns of major P450s in thioacetamide (TAA...