Delta-human epidermal growth factor receptor 2 (HER2) is a splice variant of HER2, which lacks 16 amino acids in the extracellular domain. The aim of the present study was to elucidate the expression of delta‑HER2 and its clinicopathological correlation in Japanese patients with HER2‑overexpressing breast cancer. A total of 40 cases of HER2‑overexpressing breast cancer were investigated. The mR...

in this study, we synthesized herceptin conjugated magnetic nanoparticles (hmns) as an alternative probe to discover the levels of her2 (human epidermal growth factor receptor-2) in the surface of cells. these nanoparticles can be used by magnetic resonance imaging (mri) (non-invasive methods) for screening the patients with her2 positive or negative tumors. dextran coated iron oxide nanopartic...

Some recent evidence has suggested that HER2-low breast cancers (BC) are distinct entities. The prognostic impact of low expression HER-2 not yet well defined, and inconsistent results were reported. This study aims to evaluate the status on response neoadjuvant chemotherapy (NACT). We retrospectively analyzed HER2-negative BC patients treated with NACT from 2017 2022 in a single academic cente...

Accumulating evidence indicates a functional crosstalk between the HER2 (ErbB2) tyrosine kinase and the TGF-β signaling mediated by its serine/threonine kinase receptors. In HER2-overexpressing breast cancer, this crosstalk results in increased cancer cell proliferation, survival and invasion, accelerated cancer progression and metastasis in animal models, and resistance to chemotherapy and HER...

PURPOSE Overexpression of the breast cancer oncogene HER2 correlates with poor survival. Current HER2-directed therapies confer limited clinical benefits and most patients experience progressive disease. Because refractory tumors remain strongly HER2+, vaccine approaches targeting HER2 have therapeutic potential, but wild type (wt) HER2 cannot safely be delivered in immunogenic viral vectors be...

Background and objective: The assessment of human epidermal growth factor receptor 2 (HER2) status has become of great importance in the diagnosis of breast cancer. The aim of this study was to investigate the diagnostic value of quantitative Polymerase Chain Reaction (qPCR) and Chromogenic In Situ Hybridization (CISH) to assess HER2 status of biopsy specimens. <...

The purpose of this study was to determine the change in overall survival (OS) for patients with de novo metastatic breast cancer (dnMBC) over time. We conducted a retrospective cohort 1981 dnMBC diagnosed between January 1995 and December 2017 at University Texas MD Anderson Cancer Center. OS measured from date diagnosis dnMBC. compared during different time periods: 5-year periods defined acc...

objective(s): expression of her2 in gastric carcinoma has direct prognostic and therapeutic implications in patient management. the aim of this study is to determine whether a relationship exists between standardized uptake value (suv) and expression of her2 in advanced gastric carcinoma. methods: we analyzed the 18f-fdg pet/ct results of 109 patients that underwent gastrectomy for advanced gas...