PURPOSE Anterior corneal curvature shows significant heritability. Scheimpflug imaging also permits assessment of posterior tomography. We estimated heritability of posterior and anterior tomographic parameters. METHODS Oculus Pentacam images were obtained in twins from the TwinsUK cohort. Mean anterior and posterior radii of curvature (right cornea) were compared within twin pairs, and herit...

Heritability is a concept that summarizes the proportion of phenotypic variance that is due to genetic factors, with broad-sense heritability referring to genetic variation that may include effects due to dominance and epistasis, and narrow-sense heritability referring to additive genetic variation. The popular GCTA software uses the random effects approach to estimate the narrow-sense heritabi...

Blood pressure (BP) is a heritable trait with multiple environmental and genetic contributions, with current heritability estimates from twin and family studies being ~ 40%. Here, we use genome-wide polymorphism data from the Atherosclerosis Risk in Communities (ARIC) study to estimate BP heritability from genomic relatedness among cohort members. We utilized data on 6,365,596 and 9,578,528 gen...

Nitrite and nitrate are the stable end products of the L-arginine-NO pathway, and the sum of nitrite and nitrate (NOx) is a common way to measure nitric oxide (NO) production or secretion. To uncover any genetic influence on NO, we measured NOx in serum samples from monozygotic twin pairs after an overnight fast. Heritability was estimated as intraclass correlation coefficient. We arrived at a ...

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Expected genetic response is proportional to the heritability of the trait, and this parameter is considered inherent of a specific trait in a particular population. However, models assuming heterogeneity in residual variance lead to different estimates of heritability across combinations of systematic (environmental) effects. Modifying the residual variance of the birth weight by artificial se...

We have studied heritability of the concentration of each glycolytic intermediate and adenine nucleotide in the cytosol of human erythrocytes obtained from a random sample of apparently healthy young individuals. Preliminary to analysis of heritability, each trait was statistically described and the effects attributable to variation in measured concomitants were removed by regression. Heritabil...

The heritability of genome-wide fitness that is expected in finite populations is poorly understood, both theoretically and empirically, despite its relevance to many fundamental concepts in evolutionary biology. In this study, we used two independent methods of estimating the heritability of lifetime female fecundity (the predominant female fitness component in this population) in a large, out...

It is argued that differences in response heritability may have important implications for the testing of general psychological theories, that is, responses that differ in heritability may function differently. For example, attitudes higher in heritability are shown to be responded to more quickly, to be more resistant to change, and to be more consequential in the attitude similarity attractio...

INTRODUCTION The resting ECG is the most commonly used tool to assess cardiac electrophysiology. Previous studies have estimated heritability of ECG parameters based on these snapshots of the cardiac electrical activity. In this study we set out to determine whether analysis of heart rate specific data from Holter ECGs allows more complete assessment of the heritability of ECG parameters. MET...