Background: Fish have been at high risk of atrazine toxicity. Comparative atrazine toxicity on the tissues of Clarias gariepinus is scanty. Therefore, acute and chronic effects of atrazine on some biochemical parameters in Clarias gariepinus were investigated in this study. Methods: Atrazine toxicity was determined by assessing the responses of glucose, protein, alanine aminotransferase (ALT), ...

To determine the protective effect of aloe-emodin (AE) from high glucose induced toxicity in RIN-5F (pancreatic β-cell) cell and restoration of its function was analyzed. RIN-5F cells have been cultured in high glucose (25 mM glucose) condition, with and without AE treatment. RIN-5F cells cultured in high glucose decreased cell viability and increased ROS levels after 48 hr compared with standa...

Recent findings linked the inhibition in the neuromodulator peptide endothelin-1 (ET-1) level to the high glucose-evoked neurotoxicity. However, definitive neuroprotective role for ET-1 and the major neuronal ET (ET-3) against high glucose-evoked toxicity and the implicated neurochemical responses triggered by their ET-A and ET-B receptors remain unknown. Here, we tested the hypothesis that ET-...

background: hyperglycemia is one of the important featurs of diabetes. in cell culture studies different methods are used to mimic the hyperglycemia condition. in this study we investigate response of human liver cancer cell line (hepg2) to high insulin, high glucose, and high insulin/ high glucose medium exposure. methods: hepg2 cells were settled in dmem+0.1% fbs or dmem free-serum medium wit...

Glucose degradation products (GDPs) are highly reactive precursors of advanced glycation end-products (AGEs). High glucose concentrations, GDPs, and AGEs can activate specific pathways, including inflammatory and oxidative stress response pathways, which may adversely affect the cardiovascular system. This review discusses the impact and possible mechanisms of action of GDPs and AGEs with regar...

OBJECTIVES The neuroprotective effect of fruit aqueous extract of Ziziphus jujuba Lam on glucose-induced neurotoxicity in PC12 cells as an appropriate in vitro model of diabetic neuropathy was investigated. MATERIALS AND METHODS Cell viability was determined by the MTT assay. Cellular reactive oxygen species (ROS) generation was measured by DCFH-DA analysis. Cleaved caspase-3, a biochemical p...

Glucose hypometabolism is a prominent feature of the brains of patients with Alzheimer's disease (AD). Disease progression is associated with a reduction in glucose transporters in both neurons and endothelial cells of the blood-brain barrier. However, whether increasing glucose transport into either of these cell types offers therapeutic potential remains unknown. Using an adult-onset Drosophi...

The relentless decline in -cell function frequently observed in type 2 diabetic patients, despite optimal drug management, has variously been attributed to glucose toxicity and lipotoxicity. The former theory posits hyperglycemia, an outcome of the disease, as a secondary force that further damages -cells. The latter theory suggests that the often-associated defect of hyperlipidemia is a primar...

background: the use of nanotechnology has led to rapid growth in various areas. thus, health and safety issues of nanoparticles (nps) should be promptly addressed. manganese oxide (mno2) nanoparticles (nps) are typically used for biomedical and industrial applications. however, characterizing the potential human health effects of mno2 nps is required before fully exploiting these materials. the...