Introduction: Research has shown that gold nanoparticles (AuNPs) can damage the physiological processes of brain tissue. Given the antioxidant properties of gingerol (GING), this study aimed to determine the protective effect of 6-gingerol on hippocampal levels of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), DNA oxidative damage, and the amount of Bax and Bcl2 apoptosis ...

Oxidative stress has been proposed as a possible mechanism underlying nervous system deficits associated with Fetal Alcohol Syndrome (FAS). Current research suggests that antioxidant therapy may afford some level of protection against the teratogenic effects of alcohol. This study examined the effectiveness of antioxidant treatment in alleviating biochemical, neuroanatomical, and behavioral eff...

Objective We examined genetic and dietary challenge on hippocampal oxidative damage. Mice expressing (ApoE+/+) or lacking apolipoprotein E (ApoE-/-) were maintained on a standard diet or a high fat /high cholesterol (challenge) diet for 11-31 weeks. Similar levels of oxidative species were observed for ApoE+/+ and -/- mice maintained on the basal diet. Method However, treatment of ApoE-/- hom...

The mitochondrial chaperonin Hsp60 is a ubiquitous molecule with multiple roles, constitutively expressed and inducible by oxidative stress. In the brain, Hsp60 is widely distributed and has been implicated in neurological disorders, including epilepsy. A role for mitochondria and oxidative stress has been proposed in epileptogenesis of temporal lobe epilepsy (TLE). Here, we investigated the in...

Immune molecules and redox pathways are receiving increasing attention for a possible role in pathophysiology of psychiatric disorders. A cell population that may present enhanced vulnerability to the deleterious effects of these mechanisms is the parvalbumin-positive fast spiking interneurons in cortical circuits. This cell population is thought to be affected in schizophrenia, as post-mortem ...

Nogo-A is the largest isoform of the Nogo/RTN4 (reticulon 4) proteins and has been characterized as a major myelin-associated inhibitor of regenerative nerve growth in the adult CNS (central nervous system). Apart from the myelin sheath, Nogo-A is expressed at high levels in principal neurons of the CNS. The specificity of Nogo-A resides in its central domain, NiG. We identified Apg-1, a member...

Objective: The Kii Peninsula of Japan is known to be a high incidence area of amyotrophic lateral sclerosis/parkinsonism-dementia complex (Kii ALS/PDC) with tauopathy. Nitrative stress and oxidative stress on ALS/PDC and their relationship to tau pathology were clarified. Methods: Seven patients with Kii ALS/PDC (3 males and 4 females, average age 70.7 years, 3 with ALS, 2 with ALS with dementi...

Immune molecules and redox pathways are receiving increasing attention for a possible role in pathophysiology of psychiatric disorders. A cell population that may present enhanced vulnerability to the deleterious effects of these mechanisms is the parvalbumin-positive fast spiking interneurons in cortical circuits. This cell population is thought to be affected in schizophrenia, as post-mortem ...

Immune molecules and redox pathways are receiving increasing attention for a possible role in pathophysiology of psychiatric disorders. A cell population that may present enhanced vulnerability to the deleterious effects of these mechanisms is the parvalbumin-positive fast spiking interneurons in cortical circuits. This cell population is thought to be affected in schizophrenia, as post-mortem ...