clinical cases of histoplasmosis have been reported from many parts of the world principally from the usa and to a lesser extent from central and south america. sporadic cases are recorded in medical literature from europe, africa and asia. histoplasma capsulatum, the etiologic agen of histoplasmosis is a cosmopolitan geophilic fungus associated with avian and chiroptera. the association of bat...

We report a case of Histoplasma capsulatum endocarditis in which Histoplasma antigen assay and fungal blood cultures were negative. The diagnosis was made by microscopic examination and culture of the excised valve. Histoplasma capsulatum should be considered in the differential diagnosis of culture-negative endocarditis in regions where it is endemic and in travelers.

La histoplasmosis es causada por el hongo dimórfico Histoplasma capsulatum, su infección se adquiere inhalación de conidios que a nivel pulmonar transforman en levaduras. Es considerada la micosis diseminada más prevalente Centro América. Guatemala una zona hiperendémica. Presentamos caso un paciente 6 años edad, con desnutrición crónica, historia hematoquecia y dolor abdominal 5 meses evolució...

Histoplasma capsulatum is an infrequent but serious cause of endocarditis. The definitive diagnosis requires culture, which may require a long incubation. We demonstrated the ability of the Histoplasma capsulatum AccuProbe to accurately identify this organism when applied directly on an excised valve that contained abundant yeast forms consistent with H. capsulatum.

Total synthesis of largamide H has been completed, utilising the oxidative elimination reaction of enantiomerically pure 2-amino-3-(phenylselenyl)butanoic acid residues to stereospecifically install both (Z)- and (E)-2,3-dehydro-2-aminobutanoic moieties.

A chemiluminescent DNA probe (Accuprobe) assay developed by Gen Probe, Inc., for the rapid identification of Histoplasma capsulatum was evaluated and compared with the exoantigen test by using 162 coded cultures including Histoplasma capsulatum var. capsulatum, Histoplasma capsulatum var. duboisii, Histoplasma capsulatum var. farciminosum, Blastomyces dermatitidis, Coccidioides immitis, Paracoc...

A 70-year-old male presenting a 3-month history of genital painless erythematous nodules in the balanopreputial sulcus was referred to our service. Histopathological exam presented a chronic dermatitis with epithelioid granulomas and Grocott staining revealed numerous fungal structures with a suggestive morphology of Histoplasma sp. Cultures evidenced Histoplasma capsulatum var. capsulatum. Tre...