Some new diazo incorporated coumarin compounds were designed and synthesized to evaluate their anti-HIV activity. Overall, compounds were active against HIV at 100 μM. Additionally, no cytotoxic effect was observed at this concentration. The compound with 4-chlorobenzyl group indicated the best anti-HIV activity (52%). Docking studies using the later crystallographic data available for PFV inte...

a few analogues of atevirdine or 1-[(5-methoxyindol-2-yl) carbonyl]-4-[3- (ethylamino)-2-pyridyl] piperazine – an anti-hiv belonging to non-nucleoside reverse transcriptase inhibitors were synthesized and evaluated for anti-hiv activity. replacement of indolyl moiety with 2-alkylthio-1-benzyl-5-imidazolyl substituent afforded 1-[2-(alkylthio-1-benzyl-5-imidazolyl) carbonyl]-4-[3-(isopropylamino...

Currently, the laboratory diagnostic tests available for HIV-1 viral infection are mainly based on serological testing which relies enzyme-linked immunosorbent assay (ELISA) blood HIV antigen detection and reverse transcription polymerase chain reaction (RT-PCR) specific RNA sequence identification. However, these methods expensive time-consuming, suffer from false positive and/or negative resu...