background: myasthenia gravis is an autoimmune disorder of neuromuscular junction characterized by skeletal muscle weakness and fatigability. different genes may control the induction and clinical presentation of this disease. various hla alleles are reported as predisposing or protective genetic elements in myasthenia gravis. objective: the aim of this study was to investigate the probable ass...

Background Following the launch of global COVID-19 vaccination campaign, there have been increased reports autoimmune diseases developing de novo following vaccination. These cases include rheumatoid arthritis, hepatitis, immune thrombotic thrombocytopenia, and connective tissue diseases. Nevertheless, vaccines are considered safe for patients with strongly recommended. Objectives The aim this ...

Background: It has been arguedthat unprecedented degree of human leukocyte antigen (HLA) loci polymorphism within a population is requiredto avoid the devastating effects of infectious diseases. The present study was conducted to determine the associations between some of HLA classI genes and the outcome of hepatitis B virus (HBV) infection. Methods: Using sequential sampling method, 64 individ...

Abstract In hematopoietic cell transplantation (HCT), permissive HLA-DPB1 mismatches between patients and their unrelated donors are associated with improved outcomes compared nonpermissive mismatches, but the underlying mechanism is incompletely understood. Here, we used mass spectrometry, T-cell receptor-? (TCR?) deep sequencing, cellular in vitro models of alloreactivity to interrogate HLA-D...

background: hla compatibility between transplant donor and recipient is one of the major determinants of transplant outcome. objective: to determine hla class i by pcr- sequence-specific oligonucleotide probe (pcr-ssop) in cord blood donors. methods: genomic dna of 142 cord blood samples registered at the cord blood bank of iran at hematology, oncology, and bone marrow transplantation research ...

the aim of this study was to assess the role of hla-b*27 and it’s subtypes in determining severity and clinical manifestations of ankylosing spondylitis (as). a total of 163 as patients were assessed for clinical manifestations and severity using structured questionnaires. hla-b*27 screening and b*27 sub-typing were performed by pcr. one hundred twenty two patients (74.8%) were b*27 positive. t...

Background: Interaction between killer cell immunoglobulin-like receptors (KIR) and human leukocyte antigen (HLA) class I molecules is important for regulation of natural killer (NK) cell function. Objective: The aim of this study was to investigate the impact of compound KIR-HLA genotype on susceptibility to acute leukemia. Methods: Cohorts of Iranian patients with acute myeloid leukemia (AML;...