نتایج جستجو برای: homer

تعداد نتایج: 1628  

Journal: :Molecular and cellular biology 2008
Jonathan A Stiber Zhu-Shan Zhang Jarrett Burch Jerry P Eu Sarah Zhang George A Truskey Malini Seth Naohiro Yamaguchi Gerhard Meissner Ripal Shah Paul F Worley R Sanders Williams Paul B Rosenberg

Transient receptor potential (TRP) channels are nonselective cation channels, several of which are expressed in striated muscle. Because the scaffolding protein Homer 1 has been implicated in TRP channel regulation, we hypothesized that Homer proteins play a significant role in skeletal muscle function. Mice lacking Homer 1 exhibited a myopathy characterized by decreased muscle fiber cross-sect...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2008
Paul J Kammermeier

Group I metabotropic glutamate receptors (mGluR1 and mGluR5) are important neuronal mediators of postsynaptic signaling that influence synaptic strength, plasticity, and other factors. Regulation of group I mGluR localization and function by Homer proteins appears to be a viable means for neurons to fine-tune these processes. The presence of different Homer isoforms can act as a switch to repri...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2002
Thierry T Diagana Ulrich Thomas Sergei N Prokopenko Bo Xiao Paul F Worley John B Thomas

Homer proteins have been proposed to play a role in synaptogenesis, synapse function, receptor trafficking, and axon pathfinding. Here we report the isolation and characterization of the Drosophila gene homer, the single Homer-related gene in fly. Using anti-Homer antibody we show that Homer is expressed in a broad range of tissues but is highly enriched in the CNS. Similarly to its mammalian c...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2002
Daniele Bottai John F Guzowski Martin K Schwarz Shin H Kang Bo Xiao Anthony Lanahan Paul F Worley Peter H Seeburg

Three Homer genes regulate the activity of metabotropic glutamate receptors mGluR1a and mGluR5 and their coupling to releasable intracellular Ca2+ pools and ion channels. Only the Homer 1 gene evolved bimodal expression of constitutive (Homer 1b and c) and immediate early gene (IEG) products (Homer 1a and Ania 3). The IEG forms compete functionally with the constitutive Homer proteins. The comp...

Journal: :European journal of biochemistry 2000
M M Soloviev F Ciruela W Y Chan R A McIlhinney

In order to characterize expression of Homers in mouse brain and peripheral tissues we have developed a coupled reverse transcription (RT)-PCR/restriction digestion approach. This has allowed us to determine the molecular composition and relative levels of the constitutive expression of the Homer-1, -2 and -3 mRNAs across mouse tissues. We report here that mammalian brain constitutively express...

Journal: :Neuron 1998
Bo Xiao Jian Cheng Tu Ronald S Petralia Joseph P Yuan Andrew Doan Christopher D Breder Alicia Ruggiero Anthony A Lanahan Robert J Wenthold Paul F Worley

Homer is a neuronal immediate early gene (IEG) that is enriched at excitatory synapses and binds group 1 metabotropic glutamate receptors (mGluRs). Here, we characterize a family of Homer-related proteins derived from three distinct genes. Like Homer IEG (now termed Homer 1a), all new members bind group 1 mGluRs. In contrast to Homer 1a, new members are constitutively expressed and encode a C-t...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2000
P J Kammermeier B Xiao J C Tu P F Worley S R Ikeda

Group I metabotropic glutamate receptors (mGluR1 and 5) couple to intracellular calcium pools by a family of proteins, termed Homer, that cross-link the receptor to inositol trisphosphate receptors. mGluRs also couple to membrane ion channels via G-proteins. The role of Homer proteins in channel modulation was investigated by expressing mGluRs and various forms of Homer in rat superior cervical...

Journal: :American journal of physiology. Cell physiology 2006
Elena Bortoloso Nadia Pilati Aram Megighian Elisa Tibaldo Dorianna Sandonà Pompeo Volpe

Homer represents a new and diversified family of proteins that includes several isoforms, Homer 1, 2, and 3; some of these isoforms have been reported to be present in striated muscles. In this study, the presence of Homer isoforms 1a, 1b/c/d, 2b, and 3 was thoroughly investigated in rat skeletal muscles under resting conditions. Transition in Homer isoforms compositon was studied under experim...

2002
TODD S. FROBISH

Homer’s Iliad is an epic story about human character, which predates the Aristotelian lectures by some four hundred years. While classical scholars have always valued Aristotle’s notion of ethos as a primary factor in persuasion, few have traced this concept to this earlier period. Following a close analysis of speeches in the Iliad, this examination attempts to reconstruct what Homer’s theory ...

Journal: :Molecular medicine reports 2011
Qin Hong Yan-Ping Wang Min Zhang Xiao-Qin Pan Mei Guo Fei Li Mei-Ling Tong Rong-Hua Chen Xi-Rong Guo Xia Chi

Attention-deficit/hyperactivity disorder (ADHD) is a pervasive neurobehavioral disorder. We previously demonstrated differential expression of some isoforms of Homer, a family of scaffolding proteins localized to the postsynaptic density of glutamatergic excitatory synapses, in the spontaneous hypertensive rat (SHR), which is the most frequently used animal model of ADHD. Since these changes we...

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