introduction : viral meningitis is an inflammation of the leptomeninges as a manifestation of central nervous system (cns) infection, and more than 85% of viral meningitis cases are caused by non-polio enteroviruses. molecular methods such as polymerase chain reaction (pcr) are increasingly used to detect and type non-polio enteroviruses. here, we describe the impact of these viruses on aseptic...

background and objectives : each year, enteroviruses infect millions of people and cause different diseases. the agents are usually detected using cell culture. rd (rhabdomyosarcoma) and l20b (l cells) are among the recommended cells by the world health organisation (who) for this purpose. even though cell culture is the most common method used in diagnosing enteroviruses in stool specimens, th...

For over a century, viruses have left long trail of evidence implicating them as frequent suspects in the development type 1 diabetes. Through vigorous interrogation viral infections individuals with islet autoimmunity and diabetes using serological molecular virus detection methods, well mechanistic studies virus-infected human pancreatic ?-cells, prime been narrowed down to predominantly ente...

background: human enteroviruses (evs) may have a role as a possible risk factor in the pathogenesis of mi. the aim of this study was to evaluate the presence of enterovirus genomic rna in peripheral blood samples of patients with acute myocardial infarction (mi). methods: we investigated the presence of enterovirus genomic rna in the peripheral blood of 115 patients with acute mi hospitalized i...

The Enterovirus genus of the Picornaviridae family comprises many important human pathogens, including polioviruses, rhinovirus, enterovirus A71, and enterovirus D68. They cause a wide variety of diseases, ranging from mild to severe life-threatening diseases. Currently, no effective vaccine is available against enteroviruses except for poliovirus. Enteroviruses subvert the autophagic machinery...

Sixty-six human enterovirus serotypes have been identified by serum neutralization, but the molecular determinants of the serotypes are unknown. Since the picornavirus VP1 protein contains a number of neutralization domains, we hypothesized that the VP1 sequence should correspond with neutralization (serotype) and, hence, with phylogenetic lineage. To test this hypothesis and to analyze the phy...