The effects of endopeptidase 24.11 inhibition on angiotensin-induced changes in plasma angiotensin II, aldosterone, and atrial natriuretic factor concentrations and blood pressure were assessed in normal volunteers. Two groups, each consisting of eight normal volunteers, received stepwise infusions of angiotensin II (2, 4, and 8 ng/kg per minute) on day 5 of dose administration with 25 mg every...

dietary antioxidants including phenolic compounds are believed to be effective nutrients in the prevention of oxidative stress related disease. pomegranate has been used for centuries in ancient cultures for its medicinal purpose and is widely acknowledged for antioxidant properties. the present study was designed to assess the effect of pomegranate fresh fruit consumption on the plasma antioxi...

In connection with a study to determine whether man could be successfully immunized against bacillary dysentery it was necessary to determine the infective dose of dysentery bacilli by feeding living Shigella to human volunteers. The only previous information concerning the susceptibility of man to experimental infection is contained in a few published observations' 3 of accidental laboratory-i...

The recent publication by Kelly et al. (1998) of their study on sucrose polyesters (SPE) raised concerns about the possible gastrointestinal (GI) and nutritional effects of olestra. These concerns were echoed in the popular press (‘Doubts raised over anti-obesity fat substitute’. The Times, 11 August 1998.). Olestra’s potential to cause GI and nutritional effects has been carefully reviewed by ...