The purpose of this research was to prepare a floating matrix tablet containing domperidone as a model drug. Polyethylene oxide (PEO) and hydroxypropyl methylcellulose (HPMC) were evaluated for matrix-forming properties. A simplex lattice design was applied to systemically optimize the drug release profile. The amounts of PEO WSR 303, HPMC K15M and sodium bicarbonate were selected as independen...

Novel nanocomposite films based on amylose (AM) and Fe3+-montmorillonite (Fe3+–MMT) in the matrix of poly (vinyl pyrrolidone) (PVP) were fabricated by using a solution casting method. The X-Ray diffractional analysis indicated that an ion-exchange process occurred between Fe3+–MMT and PVP. Thermogravimetrical analysis (TGA), differential termogravivetrical analy...

Aqueous (hydrophilic) and chloroform (Lipophilic) extracts of nine medicinal plants currently used in traditional medicine, in Egypt, to treat some gastrointestinal tract (GIT) disorders were tested for their gastro-protective effect against the incidence of peptic ulcer. Indomethacin-induced ulcer in a rat model was used for this testing. Mentha microphylla, Brassica oleracea Capitata (Cabbage...

Aqueous (hydrophilic) and chloroform (Lipophilic) extracts of nine medicinal plants currently used in traditional medicine, in Egypt, to treat some gastrointestinal tract (GIT) disorders were tested for their gastro-protective effect against the incidence of peptic ulcer. Indomethacin-induced ulcer in a rat model was used for this testing. Mentha microphylla, Brassica oleracea Capitata (Cabbage...

In this study, attempts were made to evaluate the effect of various acrylic acid based Carbopols on the release profile of a beta-adrenoreceptor blocking drug, propranolol HCl, from matrix-type tablets invitro. For this purpose, tablets containing 160 mg of propranolol HCl along with various amounts of Carbopols 934 (C934), 971 (C971), 974 (C974) and Pemulen (Pem) were prepared using the wet gr...