abstract background: exercise could change the immune system. it is illustrated that abnormal environments are the primary source of physiological stresses which can disarrange the function of immune system. the purpose of this study was to investigate the effects of high volume exercise (hve) in hypoxia and normoxia conduction on the immune system response in selected inactive men. materials a...

Acute mountain sickness (AMS) strikes those in the mountains who go too high too fast. Although AMS has been long assumed to be due solely to the hypoxia of high altitude, recent evidence suggests that hypobaria may also make a significant contribution to the pathophysiology of AMS. We studied nine healthy men exposed to simulated altitude, normobaric hypoxia, and normoxic hypobaria in an envir...

Background and Purpose—The usefulness of hyperbaric oxygen (HBO) and normobaric hyperoxia in acute ischemic stroke is being reexplored because both improve outcome in experimental cerebral ischemia. However, even the basic mechanisms underlying oxygen therapy are poorly understood. We investigated the effect of both oxygen therapies on tissue hypoxia and on the transcription factor hypoxia-indu...

BACKGROUND AND PURPOSE The usefulness of hyperbaric oxygen (HBO) and normobaric hyperoxia in acute ischemic stroke is being reexplored because both improve outcome in experimental cerebral ischemia. However, even the basic mechanisms underlying oxygen therapy are poorly understood. We investigated the effect of both oxygen therapies on tissue hypoxia and on the transcription factor hypoxia-indu...

We have read with interest the recent letter of SanchisGomar et al. (2010), and we basically agree with the authors who concluded that normobaric hypoxia can significantly modify several hematological parameters tested by anti-doping authorities so that anti-doping organizations should take into account the possibility of including normobaric hypoxia among the doping practices at least as a mas...

Background: Hypoxia is an intensive environmental stressor which affects the psychophysiological state of an individual. It has been confirmed to influence the fundamental frequency of voice. This study aims to investigate the effect of different hypoxia conditions on formant characteristics of voice. Method: Eighteen volunteers recorded voice using a mobile phone in two phases. Study-1: Six su...

BACKGROUND Exercise induced cardiac fatigue has recently been observed after prolonged exercise. A moderate to high altitude has been suggested as a possible stimulus in the genesis of such cardiac fatigue. OBJECTIVE To investigate if exercise induced cardiac fatigue and or cardiac damage occurs after prolonged exercise in a hypoxic environment. METHODS Eight trained male triathletes volunt...

To assess the effect of normobaric hypoxia on metabolism, gut hormones, and body composition, 11 normal weight, aerobically trained (O2peak: 60.6 ± 9.5 ml·kg(-1)·min(-1)) men (73.0 ± 7.7 kg; 23.7 ± 4.0 years, BMI 22.2 ± 2.4 kg·m(-2)) were confined to a normobaric (altitude ≃ 940 m) normoxic (NORMOXIA; PIO2 ≃ 133.2 mmHg) or normobaric hypoxic (HYPOXIA; PIO was reduced from 105.6 to 97.7 mmHg ove...

PURPOSE Hypoxia is one of the important factors in formation of reactive oxygen species (ROS). Ghrelin is a peptide hormone that reduces oxidative stress. However, antioxidant effect of ghrelin on blood and brain in normobaric hypoxia condition has not yet been investigated. METHODS thirty-two animals were randomly divided into four (n=8) experimental groups: Control (C), ghrelin (Gh), hypoxi...

Hypoxia and confinement have both been shown to influence emotional state. It is envisaged that the inhabitants of future planetary habitats will be exposed to concomitant confinement, reduced gravity and hypoxia. We examined the independent and combined effects of a 21-day inactivity/unloading and normobaric hypoxia under confined conditions on various psychological factors. Eleven healthy men...