نتایج جستجو برای: iba1

تعداد نتایج: 433  

Journal: :Journal of cell science 2000
K Ohsawa Y Imai H Kanazawa Y Sasaki S Kohsaka

Ionized calcium binding adaptor molecule 1, Iba1, is an EF hand calcium binding protein whose expression is restricted to macrophages/microglia. In this study, Iba1 was shown to colocalize with F-actin in membrane ruffles induced by macrophage colony-stimulating factor and in phagocytic cups formed during zymosan phagocytosis. Expression of mutant Iba1 carrying either N- or C-terminal deletions...

Journal: :Stroke 2001
D Ito K Tanaka S Suzuki T Dembo Y Fukuuchi

BACKGROUND AND PURPOSE Iba1 is a novel calcium-binding protein and is specifically expressed in microglia in the brain. It has been suggested that Iba1 plays an important role in regulation of the function of microglia. In the present study we examined time-dependent Iba1 expression after transient middle cerebral artery occlusion and characterized microglial activation in various brain regions...

2015
Debbie Smith Diane Brooks Eric Wohlgehagen Thomas Rau David Poulsen

We have previously demonstrated that acute treatment with low dose methamphetamine is neuroprotectivein a rat model of severe traumatic brain injury (TBI). Using gene expression analysis, we further showed that methamphetamine treatment significantly reduced the expression of proinflammatory genes after severe TBI. Therefore, to further investigate the potential effects of methamphetamine treat...

2014
Atreyi Ghatak Colin K. Combs

Antigen retrieval is a standard procedure to enhance immunohistochemical detection. However, among the many choices of techniques available for antigen retrieval, it is important to choose a method that works specifically for the antibody of interest. The small calcium binding protein, Iba1, has been well characterized as a microglia specific marker useful for identifying both resting and activ...

Journal: :The FEBS journal 2008
Jörg O Schulze Claudia Quedenau Yvette Roske Thomas Adam Herwig Schüler Joachim Behlke Andrew P Turnbull Volker Sievert Christoph Scheich Uwe Mueller Udo Heinemann Konrad Büssow

Iba2 is a homolog of ionized calcium-binding adapter molecule 1 (Iba1), a 17-kDa protein that binds and cross-links filamentous actin (F-actin) and localizes to membrane ruffles and phagocytic cups. Here, we present the crystal structure of human Iba2 and its homodimerization properties, F-actin cross-linking activity, cellular localization and recruitment upon bacterial invasion in comparison ...

Journal: :Indian journal of experimental biology 2010
Nisha Patro Aarti Nagayach I K Patro

The presence of microglia in dorsal root ganglia (DRG) has not been reported earlier. The dorsal root ganglia contain satellite glial cells (SGCs) and macrophages, which are considered to have infiltrated from the systemic blood. An attempt was made to investigate whether microglia as found in the central nervous system are also present in the dorsal root ganglia of untreated rats and following...

Journal: :Brain Behavior and Immunity 2021

Several lines of evidence suggest that neuroinflammation might be a key neurobiological mechanism depression. In particular, the P2X7 receptor (P2X7R), an ATP-gated ion channel involved in activation pro-inflammatory interleukin IL-1?, has been shown to potential new pharmacological target The aim this study was explore impact unpredictable chronic mild stress (UCMS) on behavioural changes, hip...

2016
D. Scott McLeod Imran Bhutto Malia M. Edwards Rachel E. Silver Johanna M. Seddon Gerard A. Lutty

Purpose Increasing evidence suggests a role for macrophages in the pathogenesis of age-related macular degeneration (AMD). This study examined choroidal macrophages and their activation in postmortem eyes from subjects with and without AMD. Methods Choroids were incubated with anti-ionized calcium-binding adapter molecule 1 (anti-IBA1) to label macrophages, anti-human leukocyte antigen-antige...

Journal: :Proceedings for Annual Meeting of The Japanese Pharmacological Society 2019

Journal: :Bulletin of Russian State Medical University 2022

The subfornical organ is an important regulator of water-salt metabolism and energy balance the body, involved in control cardiovascular system immune regulation. comprises several cell populations, among which microglia macrophages remain uncharacterized. This study aimed at structural, cytochemical, functional characterization rats. Brain specimens were collected from mature male Wistar rats ...

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