ige-mediated cell signaling, induced by cross-linking of high affinity receptor for ige (fcεri) in the presence of antigen (ag), is a well known mechanism described for mast cell activation in allergy and hypersensitivity reactions, which induces a spectrum of cellular responses such as secretion and up-regulation of cell surface fcεri. although for several years  ige  binding  to  fcεri  was  ...

aspergillus species (a flavus and a niger) are important sources of inhalant allergens. current  diagnostic  modalities  employ  crude  aspergillus  extracts  which  only  indicate  the source to which the patient has been sensitized, without identifying the number and type of allergens in crude extracts. we report a study on the identification of major and minor allergens of the two common air...

air pollutants are reported to increase the specific ige response to allergens. to study allergen proteins and determine the effect of air pollutants on the allergenic potential of pollen extracts, the extracts were injected intraperitoneally and subcutaneously in guinea pigs. the results were analyzed by skin prick test (spt), elisa and sds-page followed by immunoblotting. the pollen extract o...

air pollutants are reported to increase the specific ige response to allergens. clinical tests and immonoblotting were performed with pollen grains of spartium junceum. to identify allergens and to determine the effect of air pollutants on the allergenicity of the pollen extracts, the pollen extracts were injected intraperitoneally and intracutaneously to guinea pigs. injection of the pollen ex...

Because progressively earlier presentations of food allergy implicate early environmental influences, there is intense interest in the prenatal factors inducing tolerogenic immune responses. Studies eliminating food allergens during pregnancy have failed to show reduction in the prevalence of long-term IgE-mediated food allergy in children, and recent data provides direct evidence supporting ea...

Background: It appears that chronic lupoid leishmaniasis is the result of type 2 predominant T helper response to parasite and a defect in the down regulation of IL-4 production during infection. The objective of this study was to evaluate the underlying immune status in these patients and their predominant T helper activity we considered serum IgE as an indicator of TH2 activity and IL-4...

Background and Purpose: Although molds are regarded as the main fungal allergen sources, evidence indicates that spores of Basidiomycota including Agaricus bisporus (A. bisporus) can be also found at high concentrations in the environment and may cause as many respiratory allergies as molds. The aim of the present study was to evaluate specific immunoglobulin E (IgE) and immunoglobulin G (IgG) ...