the objective of the study was to compare pharmacokinetic and pharmacodynamic parameters of gliclazide after administration of immediate (ir) and modified release (mr) tablets. the experiment included rats with both normoglyceamia and streptozocin (stz)-induced hyperglyceamia. several mr formulations were designed and in vitro drug release profile was assessed by a dissolution test. for the fur...

this study was performed to design bilayer regioselective floating tablets of atenolol and lovastatin to give immediate release of lovastatin and sustained release of atenolol. bilayer floating tablets comprised two layers, i.e immediate release and controlled release layers. the immediate release layer comprised sodium starch glycollate as a super disintegrant and the sustained release layer c...

This study was performed to design bilayer regioselective floating tablets of atenolol and lovastatin to give immediate release of lovastatin and sustained release of atenolol. Bilayer floating tablets comprised two layers, i.e immediate release and controlled release layers. The immediate release layer comprised sodium starch glycollate as a super disintegrant and the sustained release layer c...

This study was performed to design bilayer regioselective floating tablets of atenolol and lovastatin to give immediate release of lovastatin and sustained release of atenolol. Bilayer floating tablets comprised two layers, i.e immediate release and controlled release layers. The immediate release layer comprised sodium starch glycollate as a super disintegrant and the sustained release layer c...

Till date, most of the drugs have been given in conventional immediate release dosage form. Nimorazole is an anticancer drug, used as a hypoxic radiosensitizer in patients undergoing radiotherapy and no formulation has been available in the market till now. Hence, for the purpose to develop an immediate release dosage form, a statistical optimization process has been employed to quantify the ef...

The development of biomedical technology is allowing refinement of drug therapies in order to improve medication profiles and benefit patients. Gabapentin (Gp) is a medication licensed globally for various indications, including postherpetic neuralgia. It has a pharmacokinetic profile which has been suggested may limit its clinical effects and reduce medication compliance. In 2012, the US Food ...

till date, most of the drugs have been given in conventional immediate release dosage form. nimorazole is an anticancer drug, used as a hypoxic radiosensitizer in patients undergoing radiotherapy and no formulation has been available in the market till now. hence, for the purpose to develop an immediate release dosage form, a statistical optimization process has been employed to quantify the ef...

We investigate the pharmacokinetics of two different cephalexin formulations administered to llamas by the intravenous (IV), intramuscular (IM), and subcutaneous (SC) routes, the minimum inhibitory concentration (MIC) of cephalexin against some Escherichia coli and staphylococci isolated from llamas, and we apply the PK/PD modelling approach, so that effective dosage recommendations for this sp...

Bacteriophage are voracious predators of bacteria and a major determinant in shaping bacterial life strategies. Many phage species are virulent, meaning that infection leads to certain death of the host and immediate release of a large batch of phage progeny. Despite this apparent voraciousness, bacteria have stably coexisted with virulent phages for eons. Here, using individual-based stochasti...