OBJECTIVE To report the outcomes of more than 100 cycles of preimplantation genetic diagnosis for monogenetic diseases. DESIGN Case series. SETTING Tertiary assisted reproductive centre in Hong Kong, where patients needed to pay for the cost of preimplantation genetic diagnosis on top of standard in-vitro fertilisation charges. PATIENTS Patients undergoing preimplantation genetic diagnosi...

  Effect of Cervical Mucus Aspiration with Insulin Syringe on Pregnancy Rate in ART Cycles     A. Aflatoonian MD1*, M. Asgharnia MD 2, N.Tabibnejad GP3     1- Associated Professor, Dept. of Gynecology, University of Medical Sciences and Research and Clinical Center of Infertility, Yazd, Iran   2- Assistant Professor, Dept. of Gynecology, Guilan University of Medical Sciences, Rasht, Iran   3- G...

Background: Hyaluronan (HA) is a structural component of extracellular matrix synthesised by HA synthases HAS1-3, which produce HA of different molecular sizes with distinct biological functions associated with reproductive processes. Hyaluronidase (HYAL) cleaves the HA into biologically active small fragments which are known to regulate cell proliferation through CD44 receptor signaling. HA is...

Background: Somatic cell nuclear transfer, commonly known as cloning is a powerful tool for the production of identical animals for productive, biomedical or conservation purposes. Today several species of mammals has been cloned using this technology. Nevertheless, the efficiency of the process is still low in terms of newborn animals. The causes for such inefficiencies are mainly the lack of ...

BACKGROUND MicroRNAs (miRNAs) are short, highly conserved small noncoding RNAs that had fundamental roles in post-transcriptional gene expression, and they are crucial for proper control of biological processes and known to participate in embryo implantation. However, miRNA expression profiles in the pre-receptive and receptive phases of the goat endometrium during embryo implantation are unkno...

The objective of this study was to evaluate, using an embryo donation model, whether impaired oocyte/embryo developmental competence and/or changes in uterine milieu are responsible for the previously observed adverse effects of superovulation with gonadotrophins on implantation and fetal development in mice. Embryos from superovulated and non-stimulated females were transferred to separate ute...

In most species, the polarity of an embryo underlies the future body plan and is determined from that of the zygote. However, mammals are thought to be an exception to this; in the mouse, polarity is generally thought to develop significantly later, only after implantation. It has not been possible, however, to relate the polarity of the preimplantation mouse embryo to that of the later concept...

Concepts of implantation physiology developed on the basis of previous work postulate that embryo implantation is initiated when trophoblast invasiveness coincides with astate of 'receptivity' of the endometrium, the latter being controlled by steroid hormones. However, neither trophoblast invasiveness nor endometrial receptivity are well understood in terms of their cell biological basis: a ro...

Previous techniques that have been used to monitor broiler embryonic temperature and metabolism during incubation either have been invasive to the embryo or have not directly determined internal egg temperature. Therefore, the current investigation was conducted to determine the earliest day of incubation on which temperature transponder implantation in the egg air cell could be performed with ...

BACKGROUND There is no doubt that luteal phase support is essential to enhance the reproductive outcome in IVF cycles. In addition to progesterone and human chorionic gonadotropin, several studies have described GnRH agonists as luteal phase support to improve implantation rate, pregnancy rate and live birth rate, whereas other studies showed dissimilar conclusions. All of these studies have be...