نتایج جستجو برای: in 1046 ah
تعداد نتایج: 16977421 فیلتر نتایج به سال:
The purpose of this investigation was to re-evaluate the neurotrophic effect of GPI-1046 on neurite outgrowth in vitro. GPI-1046 was synthesized and identified with mass spectrometry, nuclear magnetic resonance and elemental analysis. Chicken dorsal root ganglions (DRGs) were removed and divided into three groups: (1) The DRGs were cultured in DMEM containing different concentrations of GPI-104...
In vitro studies have suggested that dopamine D1- and D2-like receptors interact to inhibit renal sodium transport. We used Z-1046, a dopamine receptor agonist with the rank-order potency D3 ≥ D4 > D2 > D5 > D1, to test the hypothesis that D1- and D2-like receptors interact to inhibit renal sodium transport in vivo in anesthetized rats. Increasing doses of Z-1046, administered via the right ren...
Abstract Background Global warming and irregular changes in temperature are a serious threat to plant growth with significant negative impact on yield. maize productivity has decreased significantly due sudden fluctuations heat waves especially the regions severely hit by climate change. Results The current study demonstrates potential of beneficial bacteria for inducing tolerance during early ...
Contrasting data exist on the effect of gender and menopause on the susceptibility, development and liver damage progression in nonalcoholic fatty liver disease (NAFLD). Our aim was to assess whether menopause is associated with the severity of liver fibrosis in individuals with NAFLD and to explore the issue of ovarian senescence in experimental liver steatosis in zebrafish. In 244 females and...
Background: Most university faculty members are expected to teach. Many would benefit from instruction designed to improve lecturing. Aims: To explore the impact of a program in which video-recorded lectures were critiqued by peers. Method: Sixteen lecturers participated in this qualitative study. Four agreed to have an undergraduate lecture video-recorded for peer review. Twelve participated i...
Almorexant [(2R)-2-{(1S)-6, 7-dimethoxy-1-[2-(4-trifluoromethylphenyl)-ethyl]-3,4-dihydro-1H-isoquinolin-2-yl}-N-methyl-2-phenylacetamide], a tetrahydroisoquinoline derivative, is a dual orexin receptor antagonist with sleep-promoting properties in both animals and humans. This study investigated the disposition, metabolism, and elimination of almorexant in humans. After oral administration of ...
Although immunosuppressant immunophilin ligands promote neurite outgrowth in vitro, their neurotrophic activities are clearly independent of their immunosuppressive activity. In the present report, a novel nonimmunosuppressive immunophilin ligand, GPI-1046 (3-(3-pyridyl)-1-propyl (2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-pyrrolidinecarboxylate+ ++) is described. In vitro, GPI-1046 bound to FK506 ...
Sorbus cambrensis, WELSH WHITEBEAM, is described and illustrated. It a member of subgenus Aria unusual in being pentaploid. endemic to six sites the eastern Brecon Beacons, Wales, ‘Endangered.’ was first noted as ‘large-leaved S. porrigentiformis’ 1970s 2009. closely related another pentaploid, stenophylla, both which may be derived from hybridisation between rupicola unknown members Aria.
Nonimmunosuppressant immunophilin ligands have been found previously to stimulate neurite growth in culture and to promote regeneration of peripheral and central nerve fibers in vivo. To further characterize the effectiveness of these ligands, we have investigated the effect of the immunophilin ligand GPI-1046 in 6-hydroxydopamine (6-OHDA)-lesioned rats. In unlesioned rats, tetanic stimulation ...
3.24.1 An Introduction to the Cannabis Plant 1034 3.24.1.1 The Different Forms of Cannabis 1035 3.24.1.2 The Botany of Cannabis sativa 1035 3.24.1.3 A Short History of Cannabis 1037 3.24.1.4 Chemical Constituents of Cannabis 1038 3.24.2 Cannabinoids 1039 3.24.2.1 Cannabinoids Defined 1040 3.24.2.2 Biosynthesis of the Cannabinoids 1041 3.24.2.2.1 The acidic cannabinoids 1041 3.24.2.2.2 Occurrenc...
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