Notch and the DSL Notch ligands Delta and Serrate/Jagged are glycoproteins with a single transmembrane domain. The extracellular domain (ECD) of both Notch receptors and Notch ligands contains numerous epidermal growth factor (EGF)-like repeats which are post-translationally modified by a variety of glycans. Inactivation of a subset of genes that encode glycosyltransferases which initiate and e...

Two glycosyltransferases that transfer sugars to EGF domains, OFUT1 and Fringe, regulate Notch signaling. However, sites of O-fucosylation on Notch that influence Notch activation have not been previously identified. Moreover, the influences of OFUT1 and Fringe on Notch activation can be positive or negative, depending on their levels of expression and on whether Delta or Serrate is signaling t...

Mammalian Notch receptors contain 29-36 epidermal growth factor (EGF)-like repeats that may be modified by protein O-fucosyltransferase 1 (Pofut1), an essential component of the canonical Notch signaling pathway. The Drosophila orthologue Ofut1 is proposed to function as both a chaperone required for stable cell surface expression of Notch and a protein O-fucosyltransferase. Here we investigate...

In this paper, Microstrip patch antenna fed through an aperture coupled 50Ω microstrip line is designed for dualband and tripleband applications by cutting U-slots in the patch. When a U-slot is cut in the patch, a notch is introduced within the matching band, results in dualband antenna. If another U-slot is cut in the same patch, antenna becomes a tripleband antenna. For better coupling apert...

The trans-admittance-mode (TAM) might act as a transforming bridge for voltage-mode to current-mode conversion. In this study a new low voltage operated electronically tunable TAM biquad filter structure realizing all the seven standard filtering functions namely; low-pass (LP), band-pass (BP), high-pass (HP), regular-notch (RN), low-pass-notch (LPN), high-pass-notch (HPN) and all-pass (AP) fro...

In this paper, accumulation of plastic deformation of AISI 1045 steel plates with circular cutouts under cyclic axial loading is studied. Loading was applied under force-control conditions. Experimental tests were performed using a Zwick/Roell servo hydraulic machine. Under force-control loading with nonzero mean force, plastic strain was accumulated in continuous cycles called ratcheting. Nume...

Notch in Invertebrate Development. Notch proteins are highly conserved transmembrane receptors that are involved in cell fate regulation in invertebrates (1). While Notch receptors are initially synthesized as single polypep-tide chains proteolytic processing results in the formation of a heterodimeric receptor in which the extracellular domain is noncovalently attached to the transmembrane and...

Tracks containing CUG repeats are abundant in human gene transcripts. Their biological role includes modulation of pre-mRNA splicing, mRNA transport and regulation of translation. Expanded forms of CUG runs are associated with pathogenesis of several neurodegenerative diseases, including myotonic dystrophy type 1. We have analysed two crystal structures of RNA duplexes containing the CUG repeat...

This paper proposes a method to measure the inclined angle of an objective image based on the most frequent edge direction. This paper also describes a relation between the measured inclined angles by the proposal method and the visual inclined angles. An edge direction is changed according to the inclination of an objective image. The most frequent edge direction is supposed to show the global...