Premature Trial Suspension Will Inevitably Alter Equipoise To the Editor: The research report by the EVA-3S Investigators1 has implications which could far exceed their understandable desire to optimize safety within the trial. Following an early interim analysis, the investigators observed that the death/stroke rate after unprotected carotid angioplasty was 10.3% (6/58), as compared with 26.7%...

Abstract Agent-based models (ABMs) are increasingly important in social science research. They have two obvious apparent virtues: they can model complex macrosociological phenomena without strong assumptions about agents and analytic solutions for models, seem to instantiate the methodological individualist program a concrete way. We argue that latter claim is false. After providing schematic a...