Inorganic arsenic is a chronic exposure carcinogen. Analysis of UK baby rice revealed a median inorganic arsenic content (n=17) of 0.11 mg/kg. By plotting inorganic arsenic against total arsenic, it was found that inorganic concentrations increased linearly up to 0.25 mg/kg total arsenic, then plateaued at 0.16 mg/kg at higher total arsenic concentrations. Inorganic arsenic intake by babies (4-...

Individual variations in inorganic arsenic metabolism may influence the toxic effects. Arsenic (+3 oxidation state) methyltransferase (AS3MT) that can catalyze the transfer of a methyl group from S-adenosyl-l-methionine (AdoMet) to trivalent arsenical, may play a role in arsenic metabolism in humans. Since the genetic polymorphisms of AS3MT gene may be associated with the susceptibility to inor...

Chronic low dose inorganic arsenic exposure causes cells to take on an epithelial-to-mesenchymal phenotype, which is a crucial process in carcinogenesis. Inorganic arsenic is not a mutagen and thus epigenetic alterations have been implicated in this process. Indeed, during the epithelial-to-mesenchymal transition, morphologic changes to cells correlate with changes in chromatin structure and ge...

A novel hydride generation atomic absorption spectrometric method is developed for speciation analysis of inorganic arsenic in flours. This method is based on the leaching of arsenic from sample slurry through the sonication followed by hydride generation in the slurry and determination of the corresponding hydrides. The content of arsenic (III) [As(III)] was determined under 1% HCl acidity con...

BACKGROUND Arsenic exposure in drinking water disproportionately affects small communities in some U.S. regions, including American Indian communities. In U.S. adults with no seafood intake, median total urine arsenic is 3.4 microg/L. OBJECTIVE We evaluated arsenic exposure and excretion patterns using urine samples collected over 10 years in a random sample of American Indians from Arizona, ...

The novel dataset presented here represents the results of the changing pattern of DNA methylation profiles in HeLa cells exposed to chronic low dose (0.5 µM) sodium arsenite, resulting in epithelial-to-mesenchymal transition, as well as DNA methylation patterns in cells where inorganic arsenic has been removed. Inorganic arsenic is a known carcinogen, though not mutagenic. Several mechanisms h...

Arsenic is a natural component of the environment and is ubiquitous in soils, water, and the diet. Because dietary intake can be a significant source of background exposure to inorganic arsenic (the most toxicologically significant form), accurate intake estimates are needed to provide a context for risk management of arsenic exposure. Intake of inorganic arsenic by adults is fairly well charac...

The purpose of this study was to estimate mean concentrations of total arsenic in chicken liver tissue and then estimate total and inorganic arsenic ingested by humans through chicken consumption. We used national monitoring data from the Food Safety and Inspection Service National Residue Program to estimate mean arsenic concentrations for 1994-2000. Incorporating assumptions about the concent...

for the presentation at the EU-RL-ISS workshop 7-8 October 2013 (Rome, Italy) Arsenic speciation in food – current status on standardization of methods for specific determination of inorganic arsenic Jens J. Sloth, senior scientist, phd National Food Institute,Technical University of Denmark Division of Food Chemistry Mørkhøj Bygade 19, DK-2860 Søborg Email: [email protected] Arsenic (As) is a u...

Arsenic is a naturally occurring element, present in soil, ground water and plants. Regions with high geological occurrence of inorganic arsenic have been identified in particular in Asia and other non-European countries. In Europe, environmental arsenic levels are rather low, with the exception of distinct geological or industrial areas. Arsenic is a metalloid, displaying different valences (-...