نتایج جستجو برای: insilco
تعداد نتایج: 20 فیلتر نتایج به سال:
Alcoholism is a disease characterized by lack of a person to metabolize the alcohol efficiently. Pharmacogenomic analysis deals with study how different individuals behave towards same drug or chemical. The present work examined Insilco sequence and structural differences in the isoenzymes of alcohol dehydrogenase involved in alcohol metabolism. Methods: Experiment, identified ADH1B, ADH1A, ADH...
سابقه و هدف: ژن wdhn13 کد کننده پروتئین های گروه 2 lea می باشد. پروتئین های lea اولین بار در گندم و پنبه به عنوان پروتئین های تجمعی در اواخر دوره جنینی شناسایی و مطرح شدند. ساختار اولیه پروتئین های lea شامل دمین های اولیه باردار و بدون بار از آمینواسید های قطبی باقی مانده اما غیرآبدوست می باشد، که دلالت برآبدوست بودن پروتئین های lea دارد. مواد و روشها: در این تحقیق روابط فیلوژنتیکی و بیوانفورما...
MMPs have significant role in pathological processes and are associated with cancer invasion, and metastasis, cartilage destruction in arthritis. Non-synonymous single nucleotide polymorphisms (nsSNPs) occurring in protein coding regions of MMP potentially affect their function, and results in diseases. In this study we performed an insilco analysis of SNPs associated with MMP2 genes. Total of ...
Lack of crystal structure data of folate binding proteins has left so many questions unanswered (for example, important residues in active site, binding domain, important amino acid residues involved in interactions between ligand and receptor). With sequence alignment and PROSITE motif identification, we attempted to answer evolutionarily significant residues that are of functional importance ...
conclusions hcv gpe2 is an ideal target for hcv vaccine. prediction of epitope immunogenicity and characterization on the basis of peptide sequences will be significantly helpful for development of a heterologous vaccine against hcv variants. results many b-cell and t-cell epitopes predicted in gpe2 were found conserved among hcv 3a genotypes whereas few were conserved in other genotypes antici...
A series of derivatives (E)-6-chloro-5-fluoro-2-styryl-1H-benzo[d]imidazole, and 5-fluoro-2-methylN-phenyl-1H-benzo[d]imidazol-6-amine was synthesized. Compounds confirmed by melting point, FT-IR, 1HNMR, Mass spectral analytical techniques predicted for their ADME, Pharmacokinetic properties.Synthesized compounds screened better antibacterial antiinflammatory activity. To synthesize a novel tri...
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